Melatonin in Chinese medicinal herbs

Guofang Chen, Yushu Huo, Dun Xian Tan, Zhen Liang, Weibing Zhang, Yukui Zhang

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Melatonin is a highly conserved molecule that not only exists in animals, but also is present in bacteria, unicellular organisms and in plants. Since melatonin is an antioxidant, in plants melatonin was speculated to protect them from intrinsic and environmental oxidative stress. More importantly, melatonin in edible plants inevitably enters animals and human through feed and food. In this study, more than 100 Chinese medicinal herbs were analyzed using the methods of solid phase extraction and HPLC-FD on-line with MS to determine whether melatonin is present in these commonly used herbs. Melatonin was detected in majority of these plants. Sixty-four of them contain melatonin in excess of 10 ng per gram dry mass. Melatonin levels in several herbs are in excess of 1000 ng/g. It is well known that normal average physiological plasma levels of melatonin are only 10-60 pg/mL. These high level-melatonin containing plants are traditionally used to treat diseases which presumably involve free radical damage. The current study provides new information concerning one potentially effective constituent present in a large number of medicinal herbs. The results suggest that these herbs should be reevaluated in reference to their nutritional and medicinal value.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalLife Sciences
Volume73
Issue number1
DOIs
StatePublished - May 23 2003

Fingerprint

Melatonin
Medicinal Plants
Animals
Edible Plants
Oxidative stress
Solid Phase Extraction
Nutritive Value
Free Radicals
Bacteria
Oxidative Stress
Antioxidants
High Pressure Liquid Chromatography
Plasmas
Food
Molecules

Keywords

  • Antioxidant
  • Herbs
  • HPLC
  • Melatonin
  • MS
  • Plant

ASJC Scopus subject areas

  • Pharmacology

Cite this

Chen, G., Huo, Y., Tan, D. X., Liang, Z., Zhang, W., & Zhang, Y. (2003). Melatonin in Chinese medicinal herbs. Life Sciences, 73(1), 19-26. https://doi.org/10.1016/S0024-3205(03)00252-2

Melatonin in Chinese medicinal herbs. / Chen, Guofang; Huo, Yushu; Tan, Dun Xian; Liang, Zhen; Zhang, Weibing; Zhang, Yukui.

In: Life Sciences, Vol. 73, No. 1, 23.05.2003, p. 19-26.

Research output: Contribution to journalArticle

Chen, G, Huo, Y, Tan, DX, Liang, Z, Zhang, W & Zhang, Y 2003, 'Melatonin in Chinese medicinal herbs', Life Sciences, vol. 73, no. 1, pp. 19-26. https://doi.org/10.1016/S0024-3205(03)00252-2
Chen G, Huo Y, Tan DX, Liang Z, Zhang W, Zhang Y. Melatonin in Chinese medicinal herbs. Life Sciences. 2003 May 23;73(1):19-26. https://doi.org/10.1016/S0024-3205(03)00252-2
Chen, Guofang ; Huo, Yushu ; Tan, Dun Xian ; Liang, Zhen ; Zhang, Weibing ; Zhang, Yukui. / Melatonin in Chinese medicinal herbs. In: Life Sciences. 2003 ; Vol. 73, No. 1. pp. 19-26.
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