Abstract
Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 325-333 |
| Number of pages | 9 |
| Journal | Physiology |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2014 |
ASJC Scopus subject areas
- Physiology
Fingerprint
Dive into the research topics of 'Melatonin: Exceeding expectations'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS