TY - JOUR
T1 - Melatonin
T2 - Exceeding expectations
AU - Reiter, Russel J.
AU - Tan, Dun Xian
AU - Galano, Annia
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.
AB - Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.
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U2 - 10.1152/physiol.00011.2014
DO - 10.1152/physiol.00011.2014
M3 - Review article
C2 - 25180262
AN - SCOPUS:84906896477
VL - 29
SP - 325
EP - 333
JO - Physiology
JF - Physiology
SN - 1548-9213
IS - 5
ER -