Melatonin: Exceeding expectations

Russel J. Reiter, Dun Xian Tan, Annia Galano

Research output: Contribution to journalReview article

250 Scopus citations

Abstract

Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalPhysiology
Volume29
Issue number5
DOIs
StatePublished - Sep 1 2014

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ASJC Scopus subject areas

  • Physiology

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