Melatonin: Exceeding expectations

Russel J. Reiter; Dun Xian Tan; Annia Galano

doi:10.1152/physiol.00011.2014

Melatonin: Exceeding expectations

Russel J. Reiter, Dun Xian Tan, Annia Galano

Cell Systems & Anatomy

Research output: Contribution to journal › Review article

250 Scopus citations

Abstract

Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.

Original language	English (US)
Pages (from-to)	325-333
Number of pages	9
Journal	Physiology
Volume	29
Issue number	5
DOIs	https://doi.org/10.1152/physiol.00011.2014
State	Published - Sep 1 2014

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ASJC Scopus subject areas

Physiology

Cite this

Reiter, R. J., Tan, D. X., & Galano, A. (2014). Melatonin: Exceeding expectations. Physiology, 29(5), 325-333. https://doi.org/10.1152/physiol.00011.2014

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Access to Document

10.1152/physiol.00011.2014