Melatonin effects on prolactin secretion in pituitary-grafted female rats

A. I. Esquifino, M. A. Villanua, C. Agrasal, Russel J Reiter, J. A F Tresguerres

Research output: Contribution to journalArticle

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Abstract

Melatonin influences prolactin (PRL) secretion through unknown mechanisms. This work was undertaken to study the effects of melatonin administration of PRL secretion in pituitary-grafted female rats. Melatonin administration resulted in a marked and rapid decrease of previously high plasma PRL levels in pituitary-grafted rats. Luteinizing hormone releasing hormone (LHRH) administration resulted in a marked decrease of plasma PRL levels in both sham-operated and grafted animals given saline whereas a statistically significant increase was observed in grafted, melatonin-treated rats. Estradiol benzoate administration caused an increase in plasma PRL levels of greater magnitude in the afternoon than in the morning in sham-operated animals given saline whereas in grafted animals no response to estradiol benzoate was detected. Melatonin increased the plasma PRL response to estradiol benzoate in sham-operated rats as compared to vehicle-treated animals. A normalization of PRL response to estradiol benzoate was shown in melatonin-treated, pituitary grafted rats. While the suppressive effects of melatonin in plasma PRL levels of pituitary-grafted animals is substantial the mechanism of this inhibition remains unknown.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalJournal of Endocrinological Investigation
Volume12
Issue number3
StatePublished - 1989

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Melatonin
Prolactin
Gonadotropin-Releasing Hormone
estradiol 3-benzoate

ASJC Scopus subject areas

  • Endocrinology

Cite this

Esquifino, A. I., Villanua, M. A., Agrasal, C., Reiter, R. J., & Tresguerres, J. A. F. (1989). Melatonin effects on prolactin secretion in pituitary-grafted female rats. Journal of Endocrinological Investigation, 12(3), 171-176.

Melatonin effects on prolactin secretion in pituitary-grafted female rats. / Esquifino, A. I.; Villanua, M. A.; Agrasal, C.; Reiter, Russel J; Tresguerres, J. A F.

In: Journal of Endocrinological Investigation, Vol. 12, No. 3, 1989, p. 171-176.

Research output: Contribution to journalArticle

Esquifino, AI, Villanua, MA, Agrasal, C, Reiter, RJ & Tresguerres, JAF 1989, 'Melatonin effects on prolactin secretion in pituitary-grafted female rats', Journal of Endocrinological Investigation, vol. 12, no. 3, pp. 171-176.
Esquifino, A. I. ; Villanua, M. A. ; Agrasal, C. ; Reiter, Russel J ; Tresguerres, J. A F. / Melatonin effects on prolactin secretion in pituitary-grafted female rats. In: Journal of Endocrinological Investigation. 1989 ; Vol. 12, No. 3. pp. 171-176.
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