Melatonin: does it have utility in the treatment of haematological neoplasms?

Tian Li, Zhi Yang, Shuai Jiang, Wencheng Di, Zhiqiang Ma, Wei Hu, Fulin Chen, Russel J. Reiter, Yang Yang

Research output: Contribution to journalReview article

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Abstract

Melatonin, discovered in 1958 in the bovine pineal tissue, is an indoleamine that modulates circadian rhythms and has a wide variety of other functions. Haematological neoplasms are the leading cause of death in children and adolescents throughout the world. Research has demonstrated that melatonin is a low-toxicity protective molecule against experimental haematological neoplasms, but the mechanisms remain poorly defined. Here, we provide an introduction to haematological neoplasms and melatonin, especially as they relate to the actions of melatonin on haematological carcinogenesis. Secondly, we summarize what is known about the mechanisms of action of melatonin in the haematological system, including its pro-apoptotic, pro-oxidative, anti-proliferative and immunomodulatory actions. Thirdly, we discuss the advantages of melatonin in combination with other drugs against haematological malignancy, as well as its other benefits on the haematological system. Finally, we summarize the findings that are contrary to the suppressive effects of melatonin on cancers of haematological origin. We hope that this information will be helpful in the design of studies related to the therapeutic efficacy of melatonin in haematological neoplasms. Linked Articles: This article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc.

Original languageEnglish (US)
Pages (from-to)3251-3262
Number of pages12
JournalBritish Journal of Pharmacology
Volume175
Issue number16
DOIs
StatePublished - Aug 2018

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Li, T., Yang, Z., Jiang, S., Di, W., Ma, Z., Hu, W., Chen, F., Reiter, R. J., & Yang, Y. (2018). Melatonin: does it have utility in the treatment of haematological neoplasms? British Journal of Pharmacology, 175(16), 3251-3262. https://doi.org/10.1111/bph.13966