Melatonin: Detoxification of oxygen and nitrogen-based toxic reactants

Russel J Reiter, Dun Xian Tan, Lucien C. Manchester, Silvia Lopez-Burillo, Rosa M. Sainz, Juan C. Mayo

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

In the last decade, melatonin has been found to be highly protective against damage to macromolecules resulting from oxygen and nitrogen-based reactants. Considering this, numerous studies have examined the mechanisms whereby this indoleamine directly detoxifies these damaging agents. The evidence is compelling that melatonin scavenges several oxygen-derived reactive agents including the hydroxyl radical (OH), hydrogen peroxide (H 2O2), singlet oxygen (1O2) and hypochlorous acid (HOCl). Additionally, melatonin reportedly reacts with nitric oxide (NO), the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH) to detoxify them. In some cases the products that are formed as a consequence of melatonin's scavenging actions have been identified. Whereas the ability of melatonin to neutralize these toxic agents likely accounts, in part, for the antioxidant activity of melatonin, it is not the only means by which melatonin serves to protect molecules from oxygen and nitrogen-based reactive metabolites.

Original languageEnglish (US)
Pages (from-to)539-548
Number of pages10
JournalAdvances in Experimental Medicine and Biology
Volume527
StatePublished - 2003

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Detoxification
Poisons
Melatonin
Nitrogen
Oxygen
Peroxynitrous Acid
Hypochlorous Acid
Singlet Oxygen
Scavenging
Metabolites
Macromolecules
Hydroxyl Radical
Hydrogen Peroxide
Anions
Nitric Oxide
Antioxidants
Molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Reiter, R. J., Tan, D. X., Manchester, L. C., Lopez-Burillo, S., Sainz, R. M., & Mayo, J. C. (2003). Melatonin: Detoxification of oxygen and nitrogen-based toxic reactants. Advances in Experimental Medicine and Biology, 527, 539-548.

Melatonin : Detoxification of oxygen and nitrogen-based toxic reactants. / Reiter, Russel J; Tan, Dun Xian; Manchester, Lucien C.; Lopez-Burillo, Silvia; Sainz, Rosa M.; Mayo, Juan C.

In: Advances in Experimental Medicine and Biology, Vol. 527, 2003, p. 539-548.

Research output: Contribution to journalArticle

Reiter, RJ, Tan, DX, Manchester, LC, Lopez-Burillo, S, Sainz, RM & Mayo, JC 2003, 'Melatonin: Detoxification of oxygen and nitrogen-based toxic reactants', Advances in Experimental Medicine and Biology, vol. 527, pp. 539-548.
Reiter, Russel J ; Tan, Dun Xian ; Manchester, Lucien C. ; Lopez-Burillo, Silvia ; Sainz, Rosa M. ; Mayo, Juan C. / Melatonin : Detoxification of oxygen and nitrogen-based toxic reactants. In: Advances in Experimental Medicine and Biology. 2003 ; Vol. 527. pp. 539-548.
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