Melatonin counteracts the 5-aminolevulinic acid-induced rise of rat forebrain tryptophan and serotonin concentrations at night

S. Daya, K. O. Nonaka, Russel J Reiter

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

When rats were exposed to extended light into the normal dark phase, the administration of 5-aminolevulinic acid (5-ALA) markedly stimulated the accumulation of tryptophan (TRP) and the synthesis of serotonin (5-HT) in the forebrain. When a single injection of melatonin (25 μg) was given near the end of the 5-ALA treatment, the rise in forebrain TRP levels was either totally prevented or reversed; likewise, the increased levels of 5-HT were also suppressed. Melatonin by itself also slightly suppressed forebrain TRP levels in non-5-ALA-treated rats. Whether these are pharmacological or physiological effects of melatonin remains to be determined.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalNeuroscience Letters
Volume114
Issue number1
DOIs
StatePublished - Jun 22 1990

Fingerprint

Aminolevulinic Acid
Melatonin
Prosencephalon
Tryptophan
Serotonin
Pharmacology
Light
Injections
Therapeutics

Keywords

  • 5-Aminolevulinic acid
  • Melatonin
  • Serotonin
  • Tryptophan

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Melatonin counteracts the 5-aminolevulinic acid-induced rise of rat forebrain tryptophan and serotonin concentrations at night. / Daya, S.; Nonaka, K. O.; Reiter, Russel J.

In: Neuroscience Letters, Vol. 114, No. 1, 22.06.1990, p. 113-116.

Research output: Contribution to journalArticle

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