Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

Giuseppe Paradies, Giuseppe Petrosillo, Valeria Paradies, Russel J Reiter, Francesca M. Ruggiero

Research output: Contribution to journalArticle

279 Citations (Scopus)

Abstract

Melatonin is a natural occurring compound with well-known antioxidant properties. Melatonin is ubiquitously distributed and because of its small size and amphiphilic nature, it is able to reach easily all cellular and subcellular compartments. The highest intracellular melatonin concentrations are found in mitochondria, raising the possibility of functional significance for this targeting with involvement in situ in mitochondrial activities. Mitochondria, the powerhouse of the cell, are considered to be the most important cellular organelles to contribute to degenerative processes mainly through respiratory chain dysfunction and formation of reactive oxygen species, leading to damage to mitochondrial proteins, lipids and DNA. Therefore, protecting mitochondria from oxidative damage could be an effective therapeutic strategy against cellular degenerative processes. Many of the beneficial effects of melatonin administration may depend on its effect on mitochondrial physiology. Cardiolipin, a phospholipid located at the level of inner mitochondrial membrane is known to be intimately involved in several mitochondrial bioenergetic processes as well as in mitochondrial-dependent steps of apoptosis. Alterations to cardiolipin structure, content and acyl chain composition have been associated with mitochondrial dysfunction in multiple tissues in several physiopathological situations and aging. Recently, melatonin was reported to protect the mitochondria from oxidative damage by preventing cardiolipin oxidation and this may explain, at least in part, the beneficial effect of this molecule in mitochondrial physiopathology. In this review, we discuss the role of melatonin in preventing mitochondrial dysfunction and disease.

Original languageEnglish (US)
Pages (from-to)297-310
Number of pages14
JournalJournal of Pineal Research
Volume48
Issue number4
DOIs
StatePublished - May 2010

Fingerprint

Cardiolipins
Melatonin
Energy Metabolism
Health
Mitochondria
Mitochondrial Diseases
Mitochondrial Proteins
Mitochondrial Membranes
Electron Transport
Mitochondrial DNA
Organelles
Reactive Oxygen Species
Phospholipids
Antioxidants
Apoptosis
Lipids

Keywords

  • Cardiolipin
  • Melatonin
  • Mitochondrial physiopathology

ASJC Scopus subject areas

  • Endocrinology

Cite this

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease. / Paradies, Giuseppe; Petrosillo, Giuseppe; Paradies, Valeria; Reiter, Russel J; Ruggiero, Francesca M.

In: Journal of Pineal Research, Vol. 48, No. 4, 05.2010, p. 297-310.

Research output: Contribution to journalArticle

Paradies, Giuseppe ; Petrosillo, Giuseppe ; Paradies, Valeria ; Reiter, Russel J ; Ruggiero, Francesca M. / Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease. In: Journal of Pineal Research. 2010 ; Vol. 48, No. 4. pp. 297-310.
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