Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases

Virna Margarita Martín Giménez, Natalia de las Heras, Vicente Lahera, Jesús A.F. Tresguerres, Russel J. Reiter, Walter Manucha

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


The concept of “aging” is defined as the set of gradual and progressive changes in an organism that leads to an increased risk of weakness, disease, and death. This process may occur at the cellular and organ level, as well as in the entire organism of any living being. During aging, there is a decrease in biological functions and in the ability to adapt to metabolic stress. General effects of aging include mitochondrial, cellular, and organic dysfunction, immune impairment or inflammaging, oxidative stress, cognitive and cardiovascular alterations, among others. Therefore, one of the main harmful consequences of aging is the development and progression of multiple diseases related to these processes, especially at the cardiovascular and central nervous system levels. Both cardiovascular and neurodegenerative pathologies are highly disabling and, in many cases, lethal. In this context, melatonin, an endogenous compound naturally synthesized not only by the pineal gland but also by many cell types, may have a key role in the modulation of multiple mechanisms associated with aging. Additionally, this indoleamine is also a therapeutic agent, which may be administered exogenously with a high degree of safety. For this reason, melatonin could become an attractive and low-cost alternative for slowing the processes of aging and its associated diseases, including cardiovascular and neurodegenerative disorders.

Original languageEnglish (US)
Article number888292
JournalFrontiers in Aging Neuroscience
StatePublished - Jun 3 2022


  • aging
  • cardiovascular diseases
  • inflammation
  • melatonin
  • mitochondria
  • neurodegenerative disease
  • oxidative stress

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience


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