Melatonin and sirtuins: A “not-so unexpected” relationship

Juan C. Mayo, Rosa M. Sainz, Pedro González Menéndez, Vanesa Cepas, Dun Xian Tan, Russel J Reiter

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Epigenetic modifications, including methylation or acetylation as well as post-transcriptional modifications, are mechanisms used by eukaryotic cells to increase the genome diversity in terms of differential gene expression and protein diversity. Among these modifying enzymes, sirtuins, a class III histone deacetylase (HDAC) enzymes, are of particular importance. Sirtuins regulate the cell cycle, DNA repair, cell survival, and apoptosis, thus having important roles in normal and cancer cells. Sirtuins can also regulate metabolic pathways by changing preference for glycolysis under aerobic conditions as well as glutaminolysis. These actions make sirtuins a major target in numerous physiological processes as well as in other contexts such as calorie restriction-induced anti-aging, cancer, or neurodegenerative disease. Interestingly, melatonin, a nighttime-produced indole synthesized by pineal gland and many other organs, has important cytoprotective effects in many tissues including aging, neurodegenerative diseases, immunomodulation, and cancer. The pleiotropic actions of melatonin in different physiological and pathological conditions indicate that may be basic cellular targeted for the indole. Thus, much research has focused attention on the potential mechanisms of the indole in modulating expression and/or activity of sirtuins. Numerous findings report a rise in activity, especially on SIRT1, in a diversity of cells and animal models after melatonin treatment. This contrasts, however, with data reporting an inhibitory effect of melatonin on this sirtuin in some tumor cells. This review tabulates and discusses the recent findings relating melatonin with sirtuins, particularly SIRT1 and mitochondrial SIRT3, showing the apparent dichotomy with the differential actions documented in normal and in cancer cells.

Original languageEnglish (US)
Article numbere12391
JournalJournal of Pineal Research
Volume62
Issue number2
DOIs
StatePublished - Mar 1 2017

Fingerprint

Sirtuins
Melatonin
Neoplasms
Neurodegenerative Diseases
Physiological Phenomena
Histone Deacetylases
Pineal Gland
Immunomodulation
Eukaryotic Cells
Glycolysis
Enzymes
Acetylation
Metabolic Networks and Pathways
Epigenomics
DNA Repair
Methylation
Cell Survival
Cell Cycle
Research Design
Animal Models

Keywords

  • aging
  • apoptosis post-translational modification
  • cancer
  • deacetylases
  • mitochondria
  • SIRT1
  • SIRT3

ASJC Scopus subject areas

  • Endocrinology

Cite this

Mayo, J. C., Sainz, R. M., González Menéndez, P., Cepas, V., Tan, D. X., & Reiter, R. J. (2017). Melatonin and sirtuins: A “not-so unexpected” relationship. Journal of Pineal Research, 62(2), [e12391]. https://doi.org/10.1111/jpi.12391

Melatonin and sirtuins : A “not-so unexpected” relationship. / Mayo, Juan C.; Sainz, Rosa M.; González Menéndez, Pedro; Cepas, Vanesa; Tan, Dun Xian; Reiter, Russel J.

In: Journal of Pineal Research, Vol. 62, No. 2, e12391, 01.03.2017.

Research output: Contribution to journalReview article

Mayo, JC, Sainz, RM, González Menéndez, P, Cepas, V, Tan, DX & Reiter, RJ 2017, 'Melatonin and sirtuins: A “not-so unexpected” relationship', Journal of Pineal Research, vol. 62, no. 2, e12391. https://doi.org/10.1111/jpi.12391
Mayo JC, Sainz RM, González Menéndez P, Cepas V, Tan DX, Reiter RJ. Melatonin and sirtuins: A “not-so unexpected” relationship. Journal of Pineal Research. 2017 Mar 1;62(2). e12391. https://doi.org/10.1111/jpi.12391
Mayo, Juan C. ; Sainz, Rosa M. ; González Menéndez, Pedro ; Cepas, Vanesa ; Tan, Dun Xian ; Reiter, Russel J. / Melatonin and sirtuins : A “not-so unexpected” relationship. In: Journal of Pineal Research. 2017 ; Vol. 62, No. 2.
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