Abstract
Background: Oxidative stress (OS) arises when the balance between the production of oxidants and their removal is disturbed; OS is associated with a wide variety of health disorders. Finding strategies that efficiently reduce OS is an active area of research. Objective: This review summarizes the chemical insights concerning the antioxidant capacity (AOC) of melatonin and related compounds. Method: We consider not only naturally-occurring but also synthetic derivatives. Different chemical routes that may be involved in their AOC are analyzed and some trends in activity are provided. Conclusion: Based on the data gathered so far it can be stated that melatonin and related compounds constitute a chemical family with remarkable protective effects against OS. Their action includes both primary and secondary AOC, and –collectively-they can be considered as multifunctional protectors against OS. Current challenges and future perspectives in this area of research are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2077-2095 |
| Number of pages | 19 |
| Journal | Current Organic Chemistry |
| Volume | 21 |
| Issue number | 20 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- Antioxidant activity
- Free radical scavenging
- Kinetics
- Metal chelation
- Rate constants
- Reaction mechanisms
- Trends in activity
ASJC Scopus subject areas
- Organic Chemistry
Cite this
Melatonin and related compounds : Chemical insights into their protective effects against oxidative stress. / Galano, Annia; Tan, Dun Xian; Reiter, Russel J.
In: Current Organic Chemistry, Vol. 21, No. 20, 01.01.2017, p. 2077-2095.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Melatonin and related compounds
T2 - Chemical insights into their protective effects against oxidative stress
AU - Galano, Annia
AU - Tan, Dun Xian
AU - Reiter, Russel J
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background: Oxidative stress (OS) arises when the balance between the production of oxidants and their removal is disturbed; OS is associated with a wide variety of health disorders. Finding strategies that efficiently reduce OS is an active area of research. Objective: This review summarizes the chemical insights concerning the antioxidant capacity (AOC) of melatonin and related compounds. Method: We consider not only naturally-occurring but also synthetic derivatives. Different chemical routes that may be involved in their AOC are analyzed and some trends in activity are provided. Conclusion: Based on the data gathered so far it can be stated that melatonin and related compounds constitute a chemical family with remarkable protective effects against OS. Their action includes both primary and secondary AOC, and –collectively-they can be considered as multifunctional protectors against OS. Current challenges and future perspectives in this area of research are discussed.
AB - Background: Oxidative stress (OS) arises when the balance between the production of oxidants and their removal is disturbed; OS is associated with a wide variety of health disorders. Finding strategies that efficiently reduce OS is an active area of research. Objective: This review summarizes the chemical insights concerning the antioxidant capacity (AOC) of melatonin and related compounds. Method: We consider not only naturally-occurring but also synthetic derivatives. Different chemical routes that may be involved in their AOC are analyzed and some trends in activity are provided. Conclusion: Based on the data gathered so far it can be stated that melatonin and related compounds constitute a chemical family with remarkable protective effects against OS. Their action includes both primary and secondary AOC, and –collectively-they can be considered as multifunctional protectors against OS. Current challenges and future perspectives in this area of research are discussed.
KW - Antioxidant activity
KW - Free radical scavenging
KW - Kinetics
KW - Metal chelation
KW - Rate constants
KW - Reaction mechanisms
KW - Trends in activity
UR - http://www.scopus.com/inward/record.url?scp=85031392586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031392586&partnerID=8YFLogxK
U2 - 10.2174/1385272820666161024124058
DO - 10.2174/1385272820666161024124058
M3 - Review article
AN - SCOPUS:85031392586
VL - 21
SP - 2077
EP - 2095
JO - Current Organic Chemistry
JF - Current Organic Chemistry
SN - 1385-2728
IS - 20
ER -