Melatonin and Neonatal Sepsis

A Promising Antioxidant Adjuvant Agent

Gabriella D'angelo, Lucia Marseglia, Russel J Reiter, Giuseppe Buonocore, Eloisa Gitto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sepsis represents a major clinical problem in neonatal setting with elevated mortality rate related to multiple organ failure. Despite decades of research, the exact mechanism of organ failure in sepsis is still not completely understood. Oxidative stress (OS), derived from an imbalance between pro-oxidant and antioxidant factors, is involved in the pathogenesis of several neonatal diseases, including sepsis, and plays a particular role in systemic organ failure. Recently, it has been recognized that administration of antioxidants could be useful in septic patients. Among all antioxidants, melatonin has a characteristic role as an antioxidant, anti-inflammatory, and anti-apoptotic agent. In combination with other interventions, melatonin may contribute to an improvement in septic organ injury. Furthermore, melatonin has already been widely used in treating various diseases of neonatal population, including asphyxia, respiratory distress, and sepsis, and no significant toxicity or treatment-related side effects with long-term melatonin therapy have been reported. This review aims to summarize current knowledge concerning the potential beneficial role of melatonin in septic neonates, supporting its short-term adjuvant co-therapy to reduce complications during neonatal sepsis.

Original languageEnglish (US)
JournalAmerican Journal of Perinatology
DOIs
StateAccepted/In press - Jun 8 2017

Fingerprint

Melatonin
Antioxidants
Infant, Newborn, Diseases
Sepsis
Multiple Organ Failure
Asphyxia
Reactive Oxygen Species
Oxidative Stress
Anti-Inflammatory Agents
Therapeutics
Neonatal Sepsis
Newborn Infant
Mortality
Wounds and Injuries
Research
Population

Keywords

  • antioxidant
  • melatonin
  • newborn
  • oxidative stress
  • sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Melatonin and Neonatal Sepsis : A Promising Antioxidant Adjuvant Agent. / D'angelo, Gabriella; Marseglia, Lucia; Reiter, Russel J; Buonocore, Giuseppe; Gitto, Eloisa.

In: American Journal of Perinatology, 08.06.2017.

Research output: Contribution to journalArticle

D'angelo, Gabriella ; Marseglia, Lucia ; Reiter, Russel J ; Buonocore, Giuseppe ; Gitto, Eloisa. / Melatonin and Neonatal Sepsis : A Promising Antioxidant Adjuvant Agent. In: American Journal of Perinatology. 2017.
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