TY - JOUR
T1 - Melatonin and mitochondrial function during ischemia/reperfusion injury
AU - Ma, Zhiqiang
AU - Xin, Zhenlong
AU - Di, Wencheng
AU - Yan, Xiaolong
AU - Li, Xiaofei
AU - Reiter, Russel J.
AU - Yang, Yang
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (81500263) and China Postdoctoral Science Foundation (2016T90973 and 2015M572681).
Publisher Copyright:
© 2017, Springer International Publishing AG.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine, provides a strong defense against IR injury. Mitochondrion, an organelle for ATP production and a decider for cell fate, has been validated to be a crucial target for melatonin to exert its protection against IR injury. In this review, we first clarify the mechanisms underlying mitochondrial dysfunction during IR and melatonin’s protection of mitochondria under this condition. Thereafter, special focus is placed on the protective actions of melatonin against IR injury in brain, heart, liver, and others. Finally, we explore several potential future directions of research in this area. Collectively, the information compiled here will serve as a comprehensive reference for the actions of melatonin in IR injury identified to date and will hopefully aid in the design of future research and increase the potential of melatonin as a therapeutic agent.
AB - Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine, provides a strong defense against IR injury. Mitochondrion, an organelle for ATP production and a decider for cell fate, has been validated to be a crucial target for melatonin to exert its protection against IR injury. In this review, we first clarify the mechanisms underlying mitochondrial dysfunction during IR and melatonin’s protection of mitochondria under this condition. Thereafter, special focus is placed on the protective actions of melatonin against IR injury in brain, heart, liver, and others. Finally, we explore several potential future directions of research in this area. Collectively, the information compiled here will serve as a comprehensive reference for the actions of melatonin in IR injury identified to date and will hopefully aid in the design of future research and increase the potential of melatonin as a therapeutic agent.
KW - Ischemia/reperfusion injury
KW - Melatonin
KW - Mitochondria
KW - Oxidative stress
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U2 - 10.1007/s00018-017-2618-6
DO - 10.1007/s00018-017-2618-6
M3 - Review article
C2 - 28795196
AN - SCOPUS:85027199823
SN - 1420-682X
VL - 74
SP - 3989
EP - 3998
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 21
ER -