Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain

Daniela Melchiorri; Russel J. Reiter; Li Dun Chen; Ewa Sewerynek; Giuseppe Nisticò

doi:10.1016/0014-2999(96)00241-5

Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain

Daniela Melchiorri, Russel J. Reiter, Li Dun Chen, Ewa Sewerynek, Giuseppe Nisticò

Cell Systems & Anatomy

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Abstract

Melatonin protection against in vitro kainic acid-induced oxidative damage in rat brain is shown. Brain disrupted cell homogenates were incubated with different concentrations of kainate and with or without different concentrations of melatonin. The concentration of malonaldehyde and 4-hydroxyalkenals was measured as an index of lipid peroxidation. When administered together with kainate, melatonin produced a concentration-dependent decrease in kainate-induced lipid peroxidation ranging from 20% to 100%. Moreover, when added to the reaction mixture alone, melatonin decreased the basal level of lipid peroxidation compared to controls.

Original language	English (US)
Pages (from-to)	239-242
Number of pages	4
Journal	European Journal of Pharmacology
Volume	305
Issue number	1-3
DOIs	https://doi.org/10.1016/0014-2999(96)00241-5
State	Published - Jun 3 1996

Keywords

brain
kainate
lipid peroxidation
melatonin
rat

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(96)00241-5

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title = "Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain",

abstract = "Melatonin protection against in vitro kainic acid-induced oxidative damage in rat brain is shown. Brain disrupted cell homogenates were incubated with different concentrations of kainate and with or without different concentrations of melatonin. The concentration of malonaldehyde and 4-hydroxyalkenals was measured as an index of lipid peroxidation. When administered together with kainate, melatonin produced a concentration-dependent decrease in kainate-induced lipid peroxidation ranging from 20% to 100%. Moreover, when added to the reaction mixture alone, melatonin decreased the basal level of lipid peroxidation compared to controls.",

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AU - Melchiorri, Daniela

AU - Reiter, Russel J.

AU - Chen, Li Dun

AU - Sewerynek, Ewa

AU - Nisticò, Giuseppe

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N2 - Melatonin protection against in vitro kainic acid-induced oxidative damage in rat brain is shown. Brain disrupted cell homogenates were incubated with different concentrations of kainate and with or without different concentrations of melatonin. The concentration of malonaldehyde and 4-hydroxyalkenals was measured as an index of lipid peroxidation. When administered together with kainate, melatonin produced a concentration-dependent decrease in kainate-induced lipid peroxidation ranging from 20% to 100%. Moreover, when added to the reaction mixture alone, melatonin decreased the basal level of lipid peroxidation compared to controls.

AB - Melatonin protection against in vitro kainic acid-induced oxidative damage in rat brain is shown. Brain disrupted cell homogenates were incubated with different concentrations of kainate and with or without different concentrations of melatonin. The concentration of malonaldehyde and 4-hydroxyalkenals was measured as an index of lipid peroxidation. When administered together with kainate, melatonin produced a concentration-dependent decrease in kainate-induced lipid peroxidation ranging from 20% to 100%. Moreover, when added to the reaction mixture alone, melatonin decreased the basal level of lipid peroxidation compared to controls.

KW - brain

KW - kainate

KW - lipid peroxidation

KW - melatonin

KW - rat

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Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain

Abstract

Keywords

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