Melatonin, a toll-like receptor inhibitor: Current status and future perspectives

Omid Reza Tamtaji; Moein Mobini; Russel J. Reiter; Abolfazl Azami; Mohammad Saeed Gholami; Zatollah Asemi

doi:10.1002/jcp.27698

Melatonin, a toll-like receptor inhibitor: Current status and future perspectives

Omid Reza Tamtaji, Moein Mobini, Russel J. Reiter, Abolfazl Azami, Mohammad Saeed Gholami, Zatollah Asemi

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Toll-like receptors (TLRs) are crucial activators of inflammatory responses, they are considered immune receptors. TLRs are of fundamental importance in the pathophysiology of disorders related to inflammation including neurodegenerative diseases and cancer. Melatonin is a beneficial agent in the treatment of inflammatory and immune disorders. Melatonin is potent anti-inflammatory hormone that regulates various molecular pathways. Withal, limited studies have evaluated the inhibitory role of melatonin on TLRs. This review summarizes the current knowledge related to the effects of melatonin on TLRs in some common inflammatory and immunity disorders.

Original language	English (US)
Pages (from-to)	7788-7795
Number of pages	8
Journal	Journal of Cellular Physiology
Volume	234
Issue number	6
DOIs	https://doi.org/10.1002/jcp.27698
State	Published - Jun 2019

Keywords

inflammation
melatonin
myeloid differentiation factor 88
toll-like receptor

ASJC Scopus subject areas

Physiology
Clinical Biochemistry
Cell Biology

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10.1002/jcp.27698

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title = "Melatonin, a toll-like receptor inhibitor: Current status and future perspectives",

abstract = "Toll-like receptors (TLRs) are crucial activators of inflammatory responses, they are considered immune receptors. TLRs are of fundamental importance in the pathophysiology of disorders related to inflammation including neurodegenerative diseases and cancer. Melatonin is a beneficial agent in the treatment of inflammatory and immune disorders. Melatonin is potent anti-inflammatory hormone that regulates various molecular pathways. Withal, limited studies have evaluated the inhibitory role of melatonin on TLRs. This review summarizes the current knowledge related to the effects of melatonin on TLRs in some common inflammatory and immunity disorders.",

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AU - Reiter, Russel J.

AU - Azami, Abolfazl

AU - Gholami, Mohammad Saeed

AU - Asemi, Zatollah

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AB - Toll-like receptors (TLRs) are crucial activators of inflammatory responses, they are considered immune receptors. TLRs are of fundamental importance in the pathophysiology of disorders related to inflammation including neurodegenerative diseases and cancer. Melatonin is a beneficial agent in the treatment of inflammatory and immune disorders. Melatonin is potent anti-inflammatory hormone that regulates various molecular pathways. Withal, limited studies have evaluated the inhibitory role of melatonin on TLRs. This review summarizes the current knowledge related to the effects of melatonin on TLRs in some common inflammatory and immunity disorders.

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KW - melatonin

KW - myeloid differentiation factor 88

KW - toll-like receptor

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Melatonin, a toll-like receptor inhibitor: Current status and future perspectives

Abstract

Keywords

ASJC Scopus subject areas

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