Melatonin, a toll-like receptor inhibitor: Current status and future perspectives

Omid Reza Tamtaji, Moein Mobini, Russel J. Reiter, Abolfazl Azami, Mohammad Saeed Gholami, Zatollah Asemi

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Toll-like receptors (TLRs) are crucial activators of inflammatory responses, they are considered immune receptors. TLRs are of fundamental importance in the pathophysiology of disorders related to inflammation including neurodegenerative diseases and cancer. Melatonin is a beneficial agent in the treatment of inflammatory and immune disorders. Melatonin is potent anti-inflammatory hormone that regulates various molecular pathways. Withal, limited studies have evaluated the inhibitory role of melatonin on TLRs. This review summarizes the current knowledge related to the effects of melatonin on TLRs in some common inflammatory and immunity disorders.

Original languageEnglish (US)
Pages (from-to)7788-7795
Number of pages8
JournalJournal of Cellular Physiology
Volume234
Issue number6
DOIs
StatePublished - Jun 2019

Keywords

  • inflammation
  • melatonin
  • myeloid differentiation factor 88
  • toll-like receptor

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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