Melatonin, a toll-like receptor inhibitor

Current status and future perspectives

Omid Reza Tamtaji, Moein Mobini, Russel J Reiter, Abolfazl Azami, Mohammad Saeed Gholami, Zatollah Asemi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) are crucial activators of inflammatory responses, they are considered immune receptors. TLRs are of fundamental importance in the pathophysiology of disorders related to inflammation including neurodegenerative diseases and cancer. Melatonin is a beneficial agent in the treatment of inflammatory and immune disorders. Melatonin is potent anti-inflammatory hormone that regulates various molecular pathways. Withal, limited studies have evaluated the inhibitory role of melatonin on TLRs. This review summarizes the current knowledge related to the effects of melatonin on TLRs in some common inflammatory and immunity disorders.

Original languageEnglish (US)
JournalJournal of Cellular Physiology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Toll-Like Receptors
Melatonin
Neurodegenerative diseases
Immune System Diseases
Neurodegenerative Diseases
Immunity
Anti-Inflammatory Agents
Hormones
Inflammation
Neoplasms

Keywords

  • inflammation
  • melatonin
  • myeloid differentiation factor 88
  • toll-like receptor

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Melatonin, a toll-like receptor inhibitor : Current status and future perspectives. / Tamtaji, Omid Reza; Mobini, Moein; Reiter, Russel J; Azami, Abolfazl; Gholami, Mohammad Saeed; Asemi, Zatollah.

In: Journal of Cellular Physiology, 01.01.2018.

Research output: Contribution to journalArticle

Tamtaji, Omid Reza ; Mobini, Moein ; Reiter, Russel J ; Azami, Abolfazl ; Gholami, Mohammad Saeed ; Asemi, Zatollah. / Melatonin, a toll-like receptor inhibitor : Current status and future perspectives. In: Journal of Cellular Physiology. 2018.
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