Melatonin: A Potential Therapeutic Option for Breast Cancer

Xiangyi Kong, Ran Gao, Zhongzhao Wang, Xiangyu Wang, Yi Fang, Jidong Gao, Russel J. Reiter, Jing Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

Melatonin has significant inhibitory effects in numerous cancers, especially breast cancer. In estrogen receptor (ER)-positive human breast cancer, the oncostatic actions of melatonin are mainly achieved by suppressing ER mRNA expression and ER transcriptional activity via the MT1 receptor. Melatonin also regulates the transactivation of nuclear receptors, estrogen-metabolizing enzymes, and the expression of related genes. Furthermore, melatonin suppresses tumor aerobic glycolysis, critical cell-signaling pathways relevant to cell proliferation, survival, metastasis, and overcomes drug resistance. Studies in animal and human models indicate that disruption of the circadian nocturnal melatonin signal promotes the growth, metabolism, and signaling of human breast cancer, resulting in resistance to hormone therapy and chemotherapy, which may be reversed by melatonin.

Original languageEnglish (US)
Pages (from-to)859-871
Number of pages13
JournalTrends in Endocrinology and Metabolism
Volume31
Issue number11
DOIs
StatePublished - Nov 2020

Keywords

  • anticancer mechanism
  • breast cancer
  • melatonin
  • receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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