Abstract
Cervical cancer is one of the most common cancers between women and is known as the third leading cause of female cancer related deaths annually. Its detection in early stages allows it to be a preventable and generally treatable disease. Increasing evidence revealed, a variety of internal and external factors are associated with initiation and progression of cervical cancer pathogenesis. Human papilloma virus infection is found as a major cause of cervical cancer. Other molecular and biochemical alterations as well as genetic and epigenetic changes are related cervical cancer progression. Current treatment options often have severe side effects and toxicities thus, new adjuvant agents having synergistic effects and ability to decrease different side effects and toxicities are needed. Melatonin is an indolamine compound secreted from the pineal gland which shows wide range anticancer activities. A large amount of studies indicated inhibitory effects of melatonin against various types of cancers. In addition, experimental evidence reports inhibitory effects of melatonin as an adjuvant therapy on cervical cancer by targeting a sequence of different molecular mechanisms. Herein, for first time, we summarized anticervical cancer effects of melatonin and its underlying molecular mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21670-21682 |
| Number of pages | 13 |
| Journal | Journal of Cellular Physiology |
| Volume | 234 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- cervical cancer
- melatonin
- therapy
ASJC Scopus subject areas
- Physiology
- Clinical Biochemistry
- Cell Biology
Cite this
Melatonin : A new inhibitor agent for cervical cancer treatment. / Shafabakhsh, Rana; Reiter, Russel J; Mirzaei, Hamed; Teymoordash, Somayyeh Noei; Asemi, Zatollah.
In: Journal of Cellular Physiology, Vol. 234, No. 12, 01.01.2019, p. 21670-21682.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Melatonin
T2 - A new inhibitor agent for cervical cancer treatment
AU - Shafabakhsh, Rana
AU - Reiter, Russel J
AU - Mirzaei, Hamed
AU - Teymoordash, Somayyeh Noei
AU - Asemi, Zatollah
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Cervical cancer is one of the most common cancers between women and is known as the third leading cause of female cancer related deaths annually. Its detection in early stages allows it to be a preventable and generally treatable disease. Increasing evidence revealed, a variety of internal and external factors are associated with initiation and progression of cervical cancer pathogenesis. Human papilloma virus infection is found as a major cause of cervical cancer. Other molecular and biochemical alterations as well as genetic and epigenetic changes are related cervical cancer progression. Current treatment options often have severe side effects and toxicities thus, new adjuvant agents having synergistic effects and ability to decrease different side effects and toxicities are needed. Melatonin is an indolamine compound secreted from the pineal gland which shows wide range anticancer activities. A large amount of studies indicated inhibitory effects of melatonin against various types of cancers. In addition, experimental evidence reports inhibitory effects of melatonin as an adjuvant therapy on cervical cancer by targeting a sequence of different molecular mechanisms. Herein, for first time, we summarized anticervical cancer effects of melatonin and its underlying molecular mechanisms.
AB - Cervical cancer is one of the most common cancers between women and is known as the third leading cause of female cancer related deaths annually. Its detection in early stages allows it to be a preventable and generally treatable disease. Increasing evidence revealed, a variety of internal and external factors are associated with initiation and progression of cervical cancer pathogenesis. Human papilloma virus infection is found as a major cause of cervical cancer. Other molecular and biochemical alterations as well as genetic and epigenetic changes are related cervical cancer progression. Current treatment options often have severe side effects and toxicities thus, new adjuvant agents having synergistic effects and ability to decrease different side effects and toxicities are needed. Melatonin is an indolamine compound secreted from the pineal gland which shows wide range anticancer activities. A large amount of studies indicated inhibitory effects of melatonin against various types of cancers. In addition, experimental evidence reports inhibitory effects of melatonin as an adjuvant therapy on cervical cancer by targeting a sequence of different molecular mechanisms. Herein, for first time, we summarized anticervical cancer effects of melatonin and its underlying molecular mechanisms.
KW - cervical cancer
KW - melatonin
KW - therapy
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UR - http://www.scopus.com/inward/citedby.url?scp=85068583144&partnerID=8YFLogxK
U2 - 10.1002/jcp.28865
DO - 10.1002/jcp.28865
M3 - Review article
C2 - 31131897
AN - SCOPUS:85068583144
VL - 234
SP - 21670
EP - 21682
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
SN - 0021-9541
IS - 12
ER -