Melatonin, a mediator of electron transfer and repair reactions, acts synergistically with the chain-breaking antioxidants ascorbate, trolox and glutathione

B. Poeggeler, R. J. Reiter, R. Hardeland, E. Sewerynek, D. Melchiorri, L. R. Barlow-Walden

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

The antioxidative properties of melatonin, structurally-related indoles and the chain-breaking antioxidants ascorbate, trolox and glutathione were investigated using the radical trapping reagent ABTS (2,2'-azino-bis-3-ethylbenz-thiazoline-6-sulphonic acid). The indole compounds and the phenolic or thiolic antioxidants acted synergistically suppressing the formation of the ABTS cation radical ABTS(*)+ completely when coincubated. Electron-donating indole compounds such as melatonin and chain-breaking antioxidants such as ascorbate can act in concert to provide potent antioxidative protection.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalNeuroendocrinology Letters
Volume17
Issue number2
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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