Melatonin, a calpain inhibitor in the central nervous system: Current status and future perspectives

Omid Reza Tamtaji, Naghmeh Mirhosseini, Russel J. Reiter, Abolfazl Azami, Zatollah Asemi

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Dysregulation of neuronal Ca2+ and oxidative stress plays an important role in the activation of cysteine proteases including calpains and caspases that contribute to neuronal death. In neurodegenerative diseases, traumatic brain injury, stroke, and neuropathic pain calpain activities are markedly increased. Melatonin is a beneficial supplement in the treatment of central nervous system (CNS) disorders. Melatonin is a potent antioxidant and works as a free-radical scavenger to regulate a large number of molecular pathways, including oxidative stress, inflammation, apoptosis, and cell death under different pathological conditions. However, limited studies have evaluated the inhibitory effect of melatonin on calpains. This review summarizes the current knowledge related to the effects of melatonin on calpains in some of the common CNS disorders.

Original languageEnglish (US)
Pages (from-to)1001-1007
Number of pages7
JournalJournal of Cellular Physiology
Volume234
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • calpain
  • central nervous system
  • melatonin

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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