Melatonin, a calpain inhibitor in the central nervous system

Current status and future perspectives

Omid Reza Tamtaji, Naghmeh Mirhosseini, Russel J Reiter, Abolfazl Azami, Zatollah Asemi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Dysregulation of neuronal Ca2+ and oxidative stress plays an important role in the activation of cysteine proteases including calpains and caspases that contribute to neuronal death. In neurodegenerative diseases, traumatic brain injury, stroke, and neuropathic pain calpain activities are markedly increased. Melatonin is a beneficial supplement in the treatment of central nervous system (CNS) disorders. Melatonin is a potent antioxidant and works as a free-radical scavenger to regulate a large number of molecular pathways, including oxidative stress, inflammation, apoptosis, and cell death under different pathological conditions. However, limited studies have evaluated the inhibitory effect of melatonin on calpains. This review summarizes the current knowledge related to the effects of melatonin on calpains in some of the common CNS disorders.

Original languageEnglish (US)
JournalJournal of Cellular Physiology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Calpain
Neurology
Melatonin
Central Nervous System
Oxidative stress
Central Nervous System Diseases
Oxidative Stress
Neurodegenerative diseases
Free Radical Scavengers
Cysteine Proteases
Neuralgia
Cell death
Caspases
Neurodegenerative Diseases
Brain
Cell Death
Antioxidants
Chemical activation
Stroke
Apoptosis

Keywords

  • calpain
  • central nervous system
  • melatonin

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Melatonin, a calpain inhibitor in the central nervous system : Current status and future perspectives. / Tamtaji, Omid Reza; Mirhosseini, Naghmeh; Reiter, Russel J; Azami, Abolfazl; Asemi, Zatollah.

In: Journal of Cellular Physiology, 01.01.2018.

Research output: Contribution to journalArticle

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