Abstract
Dysregulation of neuronal Ca2+ and oxidative stress plays an important role in the activation of cysteine proteases including calpains and caspases that contribute to neuronal death. In neurodegenerative diseases, traumatic brain injury, stroke, and neuropathic pain calpain activities are markedly increased. Melatonin is a beneficial supplement in the treatment of central nervous system (CNS) disorders. Melatonin is a potent antioxidant and works as a free-radical scavenger to regulate a large number of molecular pathways, including oxidative stress, inflammation, apoptosis, and cell death under different pathological conditions. However, limited studies have evaluated the inhibitory effect of melatonin on calpains. This review summarizes the current knowledge related to the effects of melatonin on calpains in some of the common CNS disorders.
| Original language | English (US) |
|---|---|
| Journal | Journal of Cellular Physiology |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- calpain
- central nervous system
- melatonin
ASJC Scopus subject areas
- Physiology
- Clinical Biochemistry
- Cell Biology
Cite this
Melatonin, a calpain inhibitor in the central nervous system : Current status and future perspectives. / Tamtaji, Omid Reza; Mirhosseini, Naghmeh; Reiter, Russel J; Azami, Abolfazl; Asemi, Zatollah.
In: Journal of Cellular Physiology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Melatonin, a calpain inhibitor in the central nervous system
T2 - Current status and future perspectives
AU - Tamtaji, Omid Reza
AU - Mirhosseini, Naghmeh
AU - Reiter, Russel J
AU - Azami, Abolfazl
AU - Asemi, Zatollah
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Dysregulation of neuronal Ca2+ and oxidative stress plays an important role in the activation of cysteine proteases including calpains and caspases that contribute to neuronal death. In neurodegenerative diseases, traumatic brain injury, stroke, and neuropathic pain calpain activities are markedly increased. Melatonin is a beneficial supplement in the treatment of central nervous system (CNS) disorders. Melatonin is a potent antioxidant and works as a free-radical scavenger to regulate a large number of molecular pathways, including oxidative stress, inflammation, apoptosis, and cell death under different pathological conditions. However, limited studies have evaluated the inhibitory effect of melatonin on calpains. This review summarizes the current knowledge related to the effects of melatonin on calpains in some of the common CNS disorders.
AB - Dysregulation of neuronal Ca2+ and oxidative stress plays an important role in the activation of cysteine proteases including calpains and caspases that contribute to neuronal death. In neurodegenerative diseases, traumatic brain injury, stroke, and neuropathic pain calpain activities are markedly increased. Melatonin is a beneficial supplement in the treatment of central nervous system (CNS) disorders. Melatonin is a potent antioxidant and works as a free-radical scavenger to regulate a large number of molecular pathways, including oxidative stress, inflammation, apoptosis, and cell death under different pathological conditions. However, limited studies have evaluated the inhibitory effect of melatonin on calpains. This review summarizes the current knowledge related to the effects of melatonin on calpains in some of the common CNS disorders.
KW - calpain
KW - central nervous system
KW - melatonin
UR - http://www.scopus.com/inward/record.url?scp=85052430544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052430544&partnerID=8YFLogxK
U2 - 10.1002/jcp.27084
DO - 10.1002/jcp.27084
M3 - Article
C2 - 30145792
AN - SCOPUS:85052430544
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
SN - 0021-9541
ER -