TY - JOUR
T1 - Meiotic recombination
T2 - An affair of two recombinases
AU - Sehorn, Michael G.
AU - Sung, Patrick
N1 - Funding Information:
The studies in our laboratory have been supported by research grants RO1ES07061, RO1GM57814, and RO1CA96593 from the United States National Institutes of Health.
PY - 2004/11
Y1 - 2004/11
N2 - In E. coli, homologous recombination is catalyzed by the RecA recombinase. Two RecA-like factors, Rad51 and Dmc1, are found in eukaryotes. Whereas Rad51 is needed for homologous recombination reactions in both mitotic and meiotic cells, the role of Dmc1 is restricted to meiosis. Recent work has shown that, like RecA and Rad51, Dmc1 mediates the homologous DNA pairing strand exchange reaction via a filamentous intermediate assembled on single-stranded DNA. Emerging evidence suggests that the tumor suppressor BRCA2 functions in the assembly of nucleoprotein filaments of Rad51 and Dmc1. The manner in which Rad51 and Dmc1 functionally cooperate in meiotic recombination remains to be determined.
AB - In E. coli, homologous recombination is catalyzed by the RecA recombinase. Two RecA-like factors, Rad51 and Dmc1, are found in eukaryotes. Whereas Rad51 is needed for homologous recombination reactions in both mitotic and meiotic cells, the role of Dmc1 is restricted to meiosis. Recent work has shown that, like RecA and Rad51, Dmc1 mediates the homologous DNA pairing strand exchange reaction via a filamentous intermediate assembled on single-stranded DNA. Emerging evidence suggests that the tumor suppressor BRCA2 functions in the assembly of nucleoprotein filaments of Rad51 and Dmc1. The manner in which Rad51 and Dmc1 functionally cooperate in meiotic recombination remains to be determined.
KW - Chromosome segregation
KW - Homologous DNA pairing
KW - Recombinases
KW - Recombination mediators
UR - http://www.scopus.com/inward/record.url?scp=14644387434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14644387434&partnerID=8YFLogxK
U2 - 10.4161/cc.3.11.1364
DO - 10.4161/cc.3.11.1364
M3 - Short survey
C2 - 15547324
AN - SCOPUS:14644387434
SN - 1538-4101
VL - 3
SP - 1375
EP - 1377
JO - Cell Cycle
JF - Cell Cycle
IS - 11
ER -