Medullary thick limb basolateral Cl- channels

W. Brian Reeves, Christopher J. Winters, Ludwika Zimniak, Thomas E. Andreoli

Research output: Contribution to journalArticle

Abstract

Chloride transport by the medullary thick ascending limb is a major determinant of urinary concentrating and diluting power and also of tubuloglomerular feedback. In this review, we discuss the electrophysiologic, regulatory, and molecular features of a Cl-channel present in basolateral membranes from the medullary thick ascending limb. Functional and immunohistochemical data support the view that rbCIC-Ka, a CIC Cl- channel cloned from rabbit kidney medulla, may be the Cl- channel which mediates basolateral Cl- efflux.

Original languageEnglish (US)
Pages (from-to)465-470
Number of pages6
JournalWiener Klinische Wochenschrift
Volume109
Issue number12-13
StatePublished - Aug 12 1997
Externally publishedYes

Keywords

  • Anti-diuretic hormone
  • Antisense
  • Cl channel
  • Lipid bilayers
  • Thick ascending limb

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Medullary thick limb basolateral Cl<sup>-</sup> channels'. Together they form a unique fingerprint.

  • Cite this

    Reeves, W. B., Winters, C. J., Zimniak, L., & Andreoli, T. E. (1997). Medullary thick limb basolateral Cl- channels. Wiener Klinische Wochenschrift, 109(12-13), 465-470.