Medullary thick limb basolateral Cl- channels

W. Brian Reeves, Christopher J. Winters, Ludwika Zimniak, Thomas E. Andreoli

Research output: Contribution to journalArticlepeer-review


Chloride transport by the medullary thick ascending limb is a major determinant of urinary concentrating and diluting power and also of tubuloglomerular feedback. In this review, we discuss the electrophysiologic, regulatory, and molecular features of a Cl-channel present in basolateral membranes from the medullary thick ascending limb. Functional and immunohistochemical data support the view that rbCIC-Ka, a CIC Cl- channel cloned from rabbit kidney medulla, may be the Cl- channel which mediates basolateral Cl- efflux.

Original languageEnglish (US)
Pages (from-to)465-470
Number of pages6
JournalWiener Klinische Wochenschrift
Issue number12-13
StatePublished - Aug 12 1997
Externally publishedYes


  • Anti-diuretic hormone
  • Antisense
  • Cl channel
  • Lipid bilayers
  • Thick ascending limb

ASJC Scopus subject areas

  • Medicine(all)


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