Medullary thick limb basolateral Cl- channels

William B Reeves, Christopher J. Winters, Ludwika Zimniak, Thomas E. Andreoli

Research output: Contribution to journalArticle

Abstract

Chloride transport by the medullary thick ascending limb is a major determinant of urinary concentrating and diluting power and also of tubuloglomerular feedback. In this review, we discuss the electrophysiologic, regulatory, and molecular features of a Cl-channel present in basolateral membranes from the medullary thick ascending limb. Functional and immunohistochemical data support the view that rbCIC-Ka, a CIC Cl- channel cloned from rabbit kidney medulla, may be the Cl- channel which mediates basolateral Cl- efflux.

Original languageEnglish (US)
Pages (from-to)465-470
Number of pages6
JournalWiener Klinische Wochenschrift
Volume109
Issue number12-13
StatePublished - Aug 12 1997
Externally publishedYes

Fingerprint

Extremities
Kidney Medulla
Chlorides
Rabbits
Membranes

Keywords

  • Anti-diuretic hormone
  • Antisense
  • Cl channel
  • Lipid bilayers
  • Thick ascending limb

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Reeves, W. B., Winters, C. J., Zimniak, L., & Andreoli, T. E. (1997). Medullary thick limb basolateral Cl- channels. Wiener Klinische Wochenschrift, 109(12-13), 465-470.

Medullary thick limb basolateral Cl- channels. / Reeves, William B; Winters, Christopher J.; Zimniak, Ludwika; Andreoli, Thomas E.

In: Wiener Klinische Wochenschrift, Vol. 109, No. 12-13, 12.08.1997, p. 465-470.

Research output: Contribution to journalArticle

Reeves, WB, Winters, CJ, Zimniak, L & Andreoli, TE 1997, 'Medullary thick limb basolateral Cl- channels', Wiener Klinische Wochenschrift, vol. 109, no. 12-13, pp. 465-470.
Reeves WB, Winters CJ, Zimniak L, Andreoli TE. Medullary thick limb basolateral Cl- channels. Wiener Klinische Wochenschrift. 1997 Aug 12;109(12-13):465-470.
Reeves, William B ; Winters, Christopher J. ; Zimniak, Ludwika ; Andreoli, Thomas E. / Medullary thick limb basolateral Cl- channels. In: Wiener Klinische Wochenschrift. 1997 ; Vol. 109, No. 12-13. pp. 465-470.
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