Mediastinal rhabdomyoma: A case report and review of the literature

Jagmohan S. Sidhu, Marlo M. Nicolas, William Taylor

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

An incidental anterior-superior mediastinal rhabdomyoma is reported in a 68-year-old man who died of hypovolemic shock as a result of massive blood loss due to transection of aorta after being hit by a moving motor vehicle. This is the third reported case of mediastinal rhabdomyoma in the literature. The immunohistochemical evidence of expression of muscle-specific markers supports the rhabdomyomatous nature of this neoplasm, and electron microscopic demonstration of haphazardly arranged myofilaments with prominent Z bands, "jack-straws" in the mitochondria, and the absence of desmosomes is supportive of extracardiac origin of this rhabdomyoma. The possible histogenesis of extracardiac adult rhabdomyoma (EAR) in the anterior-superior mediastinum from the thymic myoid cells is also discussed.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalInternational Journal of Surgical Pathology
Volume10
Issue number4
DOIs
StatePublished - Oct 2002

Keywords

  • Mediastinum
  • Rhabdomyoma
  • Thymus

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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