MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling

Medicine and Dentistry

• Sonic Hedgehog Protein 66%
• Gene 66%
• Syndrome 66%
• Mediator 50%
• Hedgehog Signaling 50%
• Phenotype 33%
• Gene Induction 16%
• Missense Mutation 16%
• Transactivation 16%
• Congenital Malformation 16%
• Promoter Region 16%
• Coregulators 16%
• RNA Polymerase II 16%
• Intellectual Disability 16%
• X-Linked Intellectual Disability 16%
• Cells 16%
• Base 16%
• Association 16%
• Patient 16%
• Human 16%

Neuroscience

• GLI3 100%
• Sonic Hedgehog 66%
• Gene 66%
• Hedgehog Signaling Pathway 50%
• Phenotype 33%
• Intellectual Disability 33%
• Promoter Region 16%
• Missense Mutation 16%
• Transactivation 16%
• Gene Induction 16%
• RNA Polymerase II 16%