Mechanisms Regulating Transcription in Plasmodium Falciparum as Targets for Novel Antimalarial Drugs

Evelien M Bunnik, Karine G. Le Roch

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

As any organism, the human malaria parasite, Plasmodium falciparum, is dependent on a fine-tuned regulation of gene expression for its development and successful propagation. Recent insights into this process suggest that the parasite relies heavily on epigenetic mechanisms of gene regulation, more so than its human host. As we gain a better understanding of how gene expression is orchestrated in the parasite, novel avenues for the development of antimalarial therapies are opening up. In this chapter, various mechanisms that play a role in regulating transcription in the parasite are discussed, including nucleosome landscape, histone variants, histone modifications, and nuclear architecture. In addition, molecular components that are involved in these mechanisms and that may be promising targets of novel antimalarial drugs are reviewed.

Original languageEnglish (US)
Title of host publicationA Comprehensive Analysis of Parasite Biology
Subtitle of host publicationFrom Metabolism to Drug Discovery
PublisherWiley-VCH Verlag
Pages421-440
Number of pages20
ISBN (Electronic)9783527694082
ISBN (Print)9783527339044
DOIs
StatePublished - Aug 5 2016
Externally publishedYes

Keywords

  • Antimalarial drugs
  • Histone lysine demethylases
  • Histone lysine methyltransferases
  • Histone modifications
  • Histone variants
  • Nuclear architecture
  • Nucleosome landscape
  • Plasmodium falciparum
  • Regulating transcription

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Mechanisms Regulating Transcription in Plasmodium Falciparum as Targets for Novel Antimalarial Drugs'. Together they form a unique fingerprint.

Cite this