Mechanisms regulating proteostasis are involved in sympatric speciation of the blind mole rat, Spalax galili

Karl A Rodriguez, Kexin Li, Eviatar Nevo, Rochelle Buffenstein

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

ABSTRACT: Genome-wide analysis demonstrates extensive genomic adaptive complexes involved in sympatric speciation between blind mole rats (Spalax galili) in abutting populations living in basalt and chalk soils. Among the gene ontology (GO) enrichment, musculature and metabolism stood out in basalt dwellers while nutrition and neurogenetics were highlighted in chalk residents. Measurements of mechanisms regulating protein homeostasis inspired by these GO terms suggest that at the proteomic level there is also a habitat/soil-type driven divergence with the basalt residents exhibiting higher proteasome activity whereas elevated levels of markers of autophagy are evident in the chalk inhabitants.

Original languageEnglish (US)
Pages (from-to)703-704
Number of pages2
JournalAutophagy
Volume12
Issue number4
DOIs
StatePublished - Apr 2 2016

Keywords

  • 20S proteasome
  • ATG7
  • autophagic flux
  • ecological speciation
  • protein homeostasis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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