Mechanisms of kidney fibrosis and the role of antifibrotic therapies

Leo Deelman, Kumar Sharma

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Podocytes are recognized to play a key role in the development of kidney fibrosis. New antifibrotic therapies are rapidly progressing toward definitive clinical trials but will need to be tested on top of the existing therapy of renin-angiotensin system inhibition. Novel approaches targeting podocyte function would be a promising approach for early stages of the disease.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalCurrent opinion in nephrology and hypertension
Volume18
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

Keywords

  • Adiponectin
  • Angiotensin
  • Integrin-linked kinase
  • Novel therapies
  • Podocytes
  • Renal fibrosis
  • Transforming growth factor-beta

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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