Mechanisms of disease: Prostate cancer - A model for cancer chemoprevention in clinical practice

Edith D. Canby-Hagino, Ian M. Thompson

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Prostate cancer is a significant cause of cancer death, making it an attractive target for chemoprevention. Epidemiologic studies and the Prostate Cancer Prevention Trial indicate that chemoprevention is possible. Strategies for prevention include hormonal manipulation and limiting accumulation of genetic damage with anti-inflammatory agents and/or dietary antioxidants. Development of an effective chemoprevention strategy for prostate cancer is evolving and will likely serve as a model for chemoprevention of other adult malignancies.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalNature Clinical Practice Oncology
Volume2
Issue number5
DOIs
StatePublished - May 1 2005

Keywords

  • 5α-reductase
  • Antioxidants
  • Chemoprevention
  • Inflammation
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology

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