Mechanisms of cisplatin nephrotoxicity

Ronald P. Miller; Raghu K. Tadagavadi; Ganesan Ramesh; William Brian Reeves

doi:10.3390/toxins2112490

Mechanisms of cisplatin nephrotoxicity

Ronald P. Miller, Raghu K. Tadagavadi, Ganesan Ramesh, William Brian Reeves

Research output: Contribution to journal › Review article › peer-review

1350 Scopus citations

Abstract

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.

Original language	English (US)
Pages (from-to)	2490-2518
Number of pages	29
Journal	Toxins
Volume	2
Issue number	11
DOIs	https://doi.org/10.3390/toxins2112490
State	Published - Nov 2010
Externally published	Yes

Keywords

Apoptosis
Cisplatin
Cytokines
Dendritic cells
Inflammation
Kidney injury
Nephrotoxicity
Toll-like receptors

ASJC Scopus subject areas

Health, Toxicology and Mutagenesis
Toxicology

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10.3390/toxins2112490

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title = "Mechanisms of cisplatin nephrotoxicity",

abstract = "Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.",

keywords = "Apoptosis, Cisplatin, Cytokines, Dendritic cells, Inflammation, Kidney injury, Nephrotoxicity, Toll-like receptors",

author = "Miller, {Ronald P.} and Tadagavadi, {Raghu K.} and Ganesan Ramesh and Reeves, {William Brian}",

year = "2010",

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language = "English (US)",

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TY - JOUR

T1 - Mechanisms of cisplatin nephrotoxicity

AU - Miller, Ronald P.

AU - Tadagavadi, Raghu K.

AU - Ramesh, Ganesan

AU - Reeves, William Brian

PY - 2010/11

Y1 - 2010/11

N2 - Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.

AB - Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.

KW - Apoptosis

KW - Cisplatin

KW - Cytokines

KW - Dendritic cells

KW - Inflammation

KW - Kidney injury

KW - Nephrotoxicity

KW - Toll-like receptors

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U2 - 10.3390/toxins2112490

DO - 10.3390/toxins2112490

M3 - Review article

C2 - 22069563

AN - SCOPUS:79952142018

SN - 2072-6651

VL - 2

SP - 2490

EP - 2518

JO - Toxins

JF - Toxins

IS - 11

ER -

Mechanisms of cisplatin nephrotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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