Mechanisms of cisplatin nephrotoxicity

Ronald P. Miller, Raghu K. Tadagavadi, Ganesan Ramesh, William Brian Reeves

Research output: Contribution to journalReview article

676 Scopus citations

Abstract

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.

Original languageEnglish (US)
Pages (from-to)2490-2518
Number of pages29
JournalToxins
Volume2
Issue number11
DOIs
StatePublished - Nov 1 2010

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Keywords

  • Apoptosis
  • Cisplatin
  • Cytokines
  • Dendritic cells
  • Inflammation
  • Kidney injury
  • Nephrotoxicity
  • Toll-like receptors

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Miller, R. P., Tadagavadi, R. K., Ramesh, G., & Reeves, W. B. (2010). Mechanisms of cisplatin nephrotoxicity. Toxins, 2(11), 2490-2518. https://doi.org/10.3390/toxins2112490