Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city

Jason W. Bennett, Katrin Mende, Monica L. Herrera, Xin Yu, James S. Lewis, Brian L Wickes, James H. Jorgensen, Clinton K. Murray

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum β-lactamase or AmpC β-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC β-lactamase, 1 Escherichia coli expressed plasmid-mediated AmpC β-lactamase, and 1 E. cloacae produced a carbapenemase.

Original languageEnglish (US)
Pages (from-to)445-448
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume66
Issue number4
DOIs
StatePublished - Apr 2010

Fingerprint

Enterobacter cloacae
Carbapenems
Enterobacteriaceae
Membrane Proteins
Plasmids
Escherichia coli
carbapenemase
ertapenem

Keywords

  • AmpC beta-lactamase
  • Carbapenem
  • Enterobacteriaceae
  • Extended spectrum beta-lactamases
  • KPC-2
  • Porins
  • Texas city

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city. / Bennett, Jason W.; Mende, Katrin; Herrera, Monica L.; Yu, Xin; Lewis, James S.; Wickes, Brian L; Jorgensen, James H.; Murray, Clinton K.

In: Diagnostic Microbiology and Infectious Disease, Vol. 66, No. 4, 04.2010, p. 445-448.

Research output: Contribution to journalArticle

Bennett, Jason W. ; Mende, Katrin ; Herrera, Monica L. ; Yu, Xin ; Lewis, James S. ; Wickes, Brian L ; Jorgensen, James H. ; Murray, Clinton K. / Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city. In: Diagnostic Microbiology and Infectious Disease. 2010 ; Vol. 66, No. 4. pp. 445-448.
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