Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city

Jason W. Bennett, Katrin Mende, Monica L. Herrera, Xin Yu, James S. Lewis, Brian L. Wickes, James H. Jorgensen, Clinton K. Murray

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum β-lactamase or AmpC β-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC β-lactamase, 1 Escherichia coli expressed plasmid-mediated AmpC β-lactamase, and 1 E. cloacae produced a carbapenemase.

Original languageEnglish (US)
Pages (from-to)445-448
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume66
Issue number4
DOIs
StatePublished - Apr 1 2010

Keywords

  • AmpC beta-lactamase
  • Carbapenem
  • Enterobacteriaceae
  • Extended spectrum beta-lactamases
  • KPC-2
  • Porins
  • Texas city

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city'. Together they form a unique fingerprint.

Cite this