Mechanisms of antidepressant action: Is onset early or late?

Alan Frazer, Martin M. Katz

Research output: Contribution to journalReview articlepeer-review


Earlier studies of the 'onset' of antidepressant action might not have distinguished between the time when improvement first appears from when a substantial response occurs. The application of more refined statistical approaches, together with better assessments of improvement in the behavioral components of the illness, allows onset to be established in absolute terms. Recent studies, using such methodology, consistently reveal that onset of improvement occurs in two weeks or less in ultimate treatment responders.

Original languageEnglish (US)
Pages (from-to)429-433
Number of pages5
JournalDrug Discovery Today: Disease Mechanisms
Issue number4
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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