TY - JOUR
T1 - Mechanisms of alveolar bone destruction in periodontitis
AU - Schwartz, Zvi
AU - Goultschin, Josef
AU - Dean, David D.
AU - Boyan, Barbara D.
PY - 1997
Y1 - 1997
N2 - Fig. 3 summarizes the role of local factors in periodontal disease. Plaque and its associated bacteria, which populate the periodontal pocket, release lipopolysaccharide and other bacterial products to the sulcus, affecting both the immune cells in the connective tissue, as well as the osteoblasts. In the immune cells, these products induce local factor production, including IL-1α. IL-1β, IL-6, prostaglandin E2 and tumor necrosis factor α. These factors increase osteoclast formation and activation as well as inhibit osteoblast function. The bacterila products will also affect the osteoblasts directly, inhibiting their function and inducing factor production and release, eventually inducing pre-osteoclast differentiation and osteoblast activation.
AB - Fig. 3 summarizes the role of local factors in periodontal disease. Plaque and its associated bacteria, which populate the periodontal pocket, release lipopolysaccharide and other bacterial products to the sulcus, affecting both the immune cells in the connective tissue, as well as the osteoblasts. In the immune cells, these products induce local factor production, including IL-1α. IL-1β, IL-6, prostaglandin E2 and tumor necrosis factor α. These factors increase osteoclast formation and activation as well as inhibit osteoblast function. The bacterila products will also affect the osteoblasts directly, inhibiting their function and inducing factor production and release, eventually inducing pre-osteoclast differentiation and osteoblast activation.
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U2 - 10.1111/j.1600-0757.1997.tb00196.x
DO - 10.1111/j.1600-0757.1997.tb00196.x
M3 - Article
C2 - 9567970
AN - SCOPUS:0031152178
SN - 0906-6713
VL - 14
SP - 158
EP - 172
JO - Periodontology 2000
JF - Periodontology 2000
IS - 1
ER -