TY - JOUR
T1 - Mechanisms linking obesity, chronic kidney disease, and fatty liver disease
T2 - The roles of fetuin-A, adiponectin, and AMPK
AU - Ix, Joachim H.
AU - Sharma, Kumar
PY - 2010/3
Y1 - 2010/3
N2 - Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.
AB - Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.
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U2 - 10.1681/ASN.2009080820
DO - 10.1681/ASN.2009080820
M3 - Short survey
C2 - 20150538
AN - SCOPUS:77949882555
SN - 1046-6673
VL - 21
SP - 406
EP - 412
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 3
ER -