Mechanisms involved in osteoblast response to implant surface morphology

B. D. Boyan, C. H. Lohmann, David D Dean, V. L. Sylvia, David L Cochran, Zvi Schwartz

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Osteoblasts respond to surface topography with altered morphology, proliferation, and differentiation. The effects observed vary with cell culture model and the topographical features of the surface. In general, increased surface roughness is associated with decreased proliferation and increased differentiation. Cell responses to hormones, growth factors, and cytokines are altered as well, as is autocrine production of these factors. The cells interact with the surface via integrin receptors, and their expression is also surface roughness-dependent. Integrin binding to cell attachment proteins activates signal transduction cascades, including those mediated by protein kinase C and phospholipase A2. These signaling pathways are also used by regulatory factors, which results in synergistic responses. Prostaglandins are important mediators of the surface effects, and both constitutive and inducible cyclooxygenase are involved.

Original languageEnglish (US)
Pages (from-to)357-371
Number of pages15
JournalAnnual Review of Materials Science
Volume31
DOIs
StatePublished - 2001

Fingerprint

Osteoblasts
Surface morphology
Integrins
Surface roughness
Proteins
Signal transduction
Phospholipases A2
Hormones
Surface topography
Prostaglandin-Endoperoxide Synthases
Cell culture
Protein Kinase C
Prostaglandins
Intercellular Signaling Peptides and Proteins
Cytokines

Keywords

  • PGE
  • Protein kinase C
  • Surface roughness
  • Titanium

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Mechanisms involved in osteoblast response to implant surface morphology. / Boyan, B. D.; Lohmann, C. H.; Dean, David D; Sylvia, V. L.; Cochran, David L; Schwartz, Zvi.

In: Annual Review of Materials Science, Vol. 31, 2001, p. 357-371.

Research output: Contribution to journalArticle

Boyan, B. D. ; Lohmann, C. H. ; Dean, David D ; Sylvia, V. L. ; Cochran, David L ; Schwartz, Zvi. / Mechanisms involved in osteoblast response to implant surface morphology. In: Annual Review of Materials Science. 2001 ; Vol. 31. pp. 357-371.
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