Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans

Amrita Kamat, Margaret M. Hinshelwood, Barbara A. Murry, Carole R. Mendelson

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

In humans, aromatase P450, which catalyses conversion of C19-steroids to estrogens, is expressed in several tissues, including gonads, brain, adipose tissue, skin and placenta, and is encoded by a single-copy gene (CYP19); however, this does not hold true for all species. The human gene is ∼130 kb and its expression is regulated, in part, by tissue-specific promoters and by alternative splicing mechanisms. Using transgenic mouse technology, it was observed that ovary-, adipose tissue- and placenta-specific expression of human CYP19 is directed by relatively small segments of DNA within 500 bp upstream of each of the tissue-specific first exons. Thus, the use of alternative promoters allows greater versatility in tissue-specific regulation of CYP19 expression. Characterization and identification of transcription factors and crucial cis-acting elements within genomic regions that direct tissue-specific expression will contribute to improved understanding of the regulation of CYP19 expression in the tissues that synthesize estrogens under both physiological and pathophysiological conditions.

Original languageEnglish (US)
Pages (from-to)122-128
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume13
Issue number3
DOIs
StatePublished - Apr 2002
Externally publishedYes

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Aromatase
Estrogens
Placenta
Adipose Tissue
Alternative Splicing
Gonads
Transgenic Mice
Genes
Ovary
Exons
Transcription Factors
Steroids
Technology
Skin
DNA
Brain

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans. / Kamat, Amrita; Hinshelwood, Margaret M.; Murry, Barbara A.; Mendelson, Carole R.

In: Trends in Endocrinology and Metabolism, Vol. 13, No. 3, 04.2002, p. 122-128.

Research output: Contribution to journalArticle

Kamat, Amrita ; Hinshelwood, Margaret M. ; Murry, Barbara A. ; Mendelson, Carole R. / Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans. In: Trends in Endocrinology and Metabolism. 2002 ; Vol. 13, No. 3. pp. 122-128.
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