Mechanisms in intimal monocyte-macrophage recruitment: A special role for monocyte chemotactic protein-1

A. J. Valente, M. M. Rozek, E. A. Sprague, C. J. Schwartz

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

This article briefly addresses the role of the monocyte-macrophage in atherogenesis and the potential mechanisms participating in intimal blood monocyte recruitment. The obligatory components of the recruitment process, i.e., contact with the vascular endothelium, attachment, and migration into the subendothelial space, are addressed with reference to the influence of blood flow, plasma proteins (particularly low density lipoprotein), and inflammatory mediators and cytokines. The potentially important role of monocyte chemotactic protein-1 in regulating monocyte recruitment in plaque pathogenesis is discussed.

Original languageEnglish (US)
Pages (from-to)III20-III25
JournalCirculation
Volume86
Issue number6 SUPPL.
StatePublished - Jan 1 1992

Keywords

  • chemoattractants
  • molecules, adhesive
  • monocyte, intimal, recruitment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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