Mechanisms by which maternal obesity programs offspring for obesity: Evidence from animal studies

Elena Zambrano, Peter W. Nathanielsz

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Maternal obesity can profoundly affect offspring phenotype and predisposition to obesity and metabolic disease. Carefully controlled studies in precocial and altricial mammalian species provide insights into the involved mechanisms. These include programming of hypothalamic appetite-regulating centers to increase orexigenic relative to anorexigenic drive; increasing maternal, fetal, and offspring adrenal and peripheral tissue glucocorticoid production; and increasing maternal oxidative stress. Outcomes often show offspring sex differences that may play a role in the differential susceptibility of males and females to later-life obesity and other related metabolic diseases.

Original languageEnglish (US)
Pages (from-to)S42-S54
JournalNutrition Reviews
Volume71
Issue numberSUPPL1
DOIs
StatePublished - Oct 29 2013

Keywords

  • Altricial mammalian species
  • Maternal obesity
  • Offspring phenotype
  • Offspring programming mechanisms
  • Precocial mammalian species

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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