Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve

Jie Zhang, Mark S Shapiro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A-kinase anchoring proteins (AKAPs) have emerged as a converging point of diverse signals to achieve spatiotemporal resolution of directed cellular regulation. With the extensive studies of AKAP79/150 in regulation of ion channel activity, the major questions to be posed centre on the mechanism and functional role of synergistic regulation of ion channels by such signalling proteins. In this review, we summarize recent discoveries of AKAP79/150-mediated modulation of voltage-gated neuronal M-type (KCNQ, Kv7) K+ channels and L-type CaV1 Ca2+ channels, on both short- and longer-term time scales, highlighting the dynamics of the macromolecular signalling complexes in brain and peripheral nerve We also discuss several models for the possible mechanisms of these multi-protein assemblies and how they serve the agenda of the neurons in which they occur.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalJournal of Physiology
Volume594
Issue number1
DOIs
StatePublished - Jan 1 2016

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Ion Channels
Peripheral Nerves
Macromolecular Substances
Brain
Protein Kinases
Proteins
Neurons

ASJC Scopus subject areas

  • Physiology

Cite this

Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve. / Zhang, Jie; Shapiro, Mark S.

In: Journal of Physiology, Vol. 594, No. 1, 01.01.2016, p. 31-37.

Research output: Contribution to journalArticle

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