Mechanism of Hypocalcemic Effect of Inorganic Phosphate

Tapan K. Chaudhuri, Tuhin K. Chaudhuri

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


The plasma calcium-lowering effect of phosphate administration has been known since 1932,1 although its use in the management of hypercalcemic crisis has only recently become accepted.23 However, the exact fate of calcium removed from the blood is still uncertain. There are several theories — namely, theory of decreased bone resorption12 and theory of increased bone formation.4. Extraskeletal deposition of calcium was suggested by Hebert et al.5 as another theoretical mechanism, but the exact anatomic site was obscure. Our experimental observations67 with radioisotopes of strontium and calcium in animals suggest that phosphate forms presumably a colloid of.

Original languageEnglish (US)
Pages (from-to)691
Number of pages1
JournalNew England Journal of Medicine
Issue number12
StatePublished - Sep 16 1971
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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