Mechanism of homologous recombination: Mediators and helicases take on regulatory functions

Patrick Sung, Hannah Klein

Research output: Contribution to journalReview articlepeer-review

432 Scopus citations

Abstract

Homologous recombination (HR) is an important mechanism for the repair of damaged chromosomes, for preventing the demise of damaged replication forks, and for several other aspects of chromosome maintenance. As such, HR is indispensable for genome integrity, but it must be regulated to avoid deleterious events. Mutations in the tumour-suppressor protein BRCA2, which has a mediator function in HR, lead to cancer formation. DNA helicases, such as Bloom's syndrome protein (BLM), regulate HR at several levels, in attenuating unwanted HR events and in determining the outcome of HR. Defects in BLM are also associated with the cancer phenotype. The past several years have witnessed dramatic advances in our understanding of the mechanism and regulation of HR.

Original languageEnglish (US)
Pages (from-to)739-750
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume7
Issue number10
DOIs
StatePublished - Oct 23 2006
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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