Mechanism of enhanced parathion/paraoxon toxicity during pregnancy in the mouse

Steven D Weitman, Mary Jo Vodicinik, John J. Lech

Research output: Contribution to journalArticle

Abstract

Mechanism of Enhanced Parathion/Paraoxon Toxicity during Pregnancy in the Mouse. WEITMAN, S. D., VODICNIK, M. J., AND LECH, J. J. (1986). Fundam Appl Toxicol. 6, 155-161. The mechanism of enhanced parathion/paraoxon toxicity during pregnancy was examined. Enhanced toxicity following exposure to paraoxon in the pregnant mouse as determined by cholinesterase suppression was observed at 0.10 and 0.58 mg/kg after ip administration on Day 19 of gestation. However, there were no significant differences in cholinesterase activity between pregnant animals and virgin controls after either po or iv paraoxon. Higher systemic and lower hepatic levels of parathion were demonstrated in pregnant mice following ip administration of parathion (5 mg/kg). Data herein also suggest that during pregnancy, larger quantities of paraoxon bypass initial liver detoxification after ip dosing. The mechanism of increased toxicity of parathion/paraoxon during pregnancy may result from alterations in absorption from the peritoneal cavity.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalToxicological Sciences
Volume6
Issue number1
DOIs
StatePublished - Jan 1986
Externally publishedYes

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Paraoxon
Parathion
Toxicity
Pregnancy
Cholinesterases
Detoxification
Liver
Peritoneal Cavity
Animals

ASJC Scopus subject areas

  • Molecular Biology
  • Embryology
  • Cell Biology
  • Genetics
  • Developmental Biology
  • Toxicology

Cite this

Mechanism of enhanced parathion/paraoxon toxicity during pregnancy in the mouse. / Weitman, Steven D; Vodicinik, Mary Jo; Lech, John J.

In: Toxicological Sciences, Vol. 6, No. 1, 01.1986, p. 155-161.

Research output: Contribution to journalArticle

Weitman, Steven D ; Vodicinik, Mary Jo ; Lech, John J. / Mechanism of enhanced parathion/paraoxon toxicity during pregnancy in the mouse. In: Toxicological Sciences. 1986 ; Vol. 6, No. 1. pp. 155-161.
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