Mechanism of dietary modulation of calcitonin levels in Fischer rats

D. N. Kalu, D. C. Herbert, R. R. Hardin, B. P. Yu, G. Kaplan, J. W. Jacobs

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Aging caused an increase in serum calcitonin that was markedly suppressed by food restriction. Food restriction had no significant effect on gut calcium absorption, urinary calcium excretion, serum 1,25 (OH)2vitamin D, blood ionized calcium, the clearance of calcitonin from plasma, and its rate of inactivation in vitro by the kidney and liver. In contrast, food restriction modulated an increase with age in calcitonin secreting C-cells, thyroidal calcitonin and thyroidal calcitonin mRNA pools. We conclude that the lowering of age-related increase in serum calcitonin levels by food restriction is likely because of lowered thyroid calcitonin pools rather than changes in the metabolism of calcium, which is the primary stimulus for calcitonin secretion. Our findings also suggest that food restriction decreases age-related increase in calcitonin levels, at least in part, by modulating the expression of the calcitonin gene.

Original languageEnglish (US)
Pages (from-to)B125-B131
JournalJournals of Gerontology
Volume43
Issue number5
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Aging

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