Abstract
Background: Pain is an important clinical manifestation in multiple sclerosis (MS) patients, though it has been neglected in clinical and experimental researches. Objective: To investigate the nociceptive response in MOG35-55 experimental autoimmune encephalomyelitis (EAE)-induced mice. Method: EAE was induced in 8 to 10 week old C57BL/6 female mice with an emulsion of MOG35-55, Complete Freund Adjuvant, Mycobacterium tuberculosis H37 RA and pertussis toxin. Nociception was evaluated by the von Frey filaments method. A clinical scale ranging from 0 to 15 was used to assess motor impairment. Results: Clinical evidence of disease started at day 10 and peaked at day 14 after immunization. Thereafter, there was no worsening of symptoms until day 26. The EAE-induced mice presented reduced pressure threshold at days 7th and 10th after immunization and before the onset of clinical motor signs. Conclusion: The hypemociception found validates MOG35-55 EAE as a model for the study of pain in multiple sclerosis.
Original language | English (US) |
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Pages (from-to) | 78-81 |
Number of pages | 4 |
Journal | Arquivos de neuro-psiquiatria |
Volume | 67 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2009 |
Externally published | Yes |
Keywords
- Experimental autoimmune encephalomyelitis
- Hyperalgesia
- Mechanical hypernociception
- Multiple sclerosis
ASJC Scopus subject areas
- Clinical Neurology
- Biological Psychiatry