TY - JOUR
T1 - Mecamylamine prevents the enhancement of retention induced by lysine vasopressin in mice
AU - Faiman, Claudia P.
AU - De Erausquin, Gabriel A.
AU - Baratti, Carlos M.
PY - 1987/11
Y1 - 1987/11
N2 - Lysine vasopressin (0.03 μg/kg, sc) enhanced retention of a one-trial, step-through inhibitory avoidance task when injected into male Swiss mice immediately post-training, as indicated by retention performance 48 h later. A low dose of the vasopressin antagonist, AAVP (0.01 μg/kg, sc), did not significantly affect retention, whereas a higher dose (0.03 μg/kg, sc) impaired retention. Neither lysine vasopressin nor AAVP modified latencies to step-through of mice that had not received a footshock during training. The simultaneous injection of AAVP (0.01 μg/kg, sc) prevented the enhancement of retention induced by lysine vasopressin. The influence of lysine vasopressin on retention was antagonized by the simultaneous administration of mecamylamine (5 mg/kg, sc) but not by hexamethonium (5 mg/kg, sc), atropine (0.5 mg/kg, sc), or methylatropine (0.5 mg/kg, sc). A modulatory role of vasopressin on the activity of central cholinergic nicotinic mechanisms which participate in memory formation is suggested.
AB - Lysine vasopressin (0.03 μg/kg, sc) enhanced retention of a one-trial, step-through inhibitory avoidance task when injected into male Swiss mice immediately post-training, as indicated by retention performance 48 h later. A low dose of the vasopressin antagonist, AAVP (0.01 μg/kg, sc), did not significantly affect retention, whereas a higher dose (0.03 μg/kg, sc) impaired retention. Neither lysine vasopressin nor AAVP modified latencies to step-through of mice that had not received a footshock during training. The simultaneous injection of AAVP (0.01 μg/kg, sc) prevented the enhancement of retention induced by lysine vasopressin. The influence of lysine vasopressin on retention was antagonized by the simultaneous administration of mecamylamine (5 mg/kg, sc) but not by hexamethonium (5 mg/kg, sc), atropine (0.5 mg/kg, sc), or methylatropine (0.5 mg/kg, sc). A modulatory role of vasopressin on the activity of central cholinergic nicotinic mechanisms which participate in memory formation is suggested.
UR - http://www.scopus.com/inward/record.url?scp=0023619126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023619126&partnerID=8YFLogxK
U2 - 10.1016/S0163-1047(87)90996-4
DO - 10.1016/S0163-1047(87)90996-4
M3 - Article
C2 - 3689289
AN - SCOPUS:0023619126
SN - 0163-1047
VL - 48
SP - 434
EP - 439
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 3
ER -