Mecamylamine blockade of nicotine enhanced noradrenaline turnover in rat brain

William W. Morgan, Karla A. Pfeil

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The administration of nicotine significantly enhanced the depletion in noradrenaline (NA) observed in the brains of male Sprague-Dawley rats following alpha methyl-para-tyrosine (αMPT) administration. These data indicate that nicotine enhances the turnover of NA in the rat brain. This effect of nicotine was completely blocked by mecamylamine administration while mecamylamine alone had no observed effect on NA content or turnover. These data are consistent with the action of mecamylamine as an effective antagonist of the action of nicotine in the rat brain.

Original languageEnglish (US)
Pages (from-to)417-420
Number of pages4
JournalLife Sciences
Volume24
Issue number5
DOIs
StatePublished - Jan 29 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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