The administration of nicotine significantly enhanced the depletion in noradrenaline (NA) observed in the brains of male Sprague-Dawley rats following alpha methyl-para-tyrosine (αMPT) administration. These data indicate that nicotine enhances the turnover of NA in the rat brain. This effect of nicotine was completely blocked by mecamylamine administration while mecamylamine alone had no observed effect on NA content or turnover. These data are consistent with the action of mecamylamine as an effective antagonist of the action of nicotine in the rat brain.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)