Measurements of protein binding of lidocaine throughout pregnancy

R. Y. Fragneto, A. M. Bader, F. Rosinia, G. R. Arthur, S. Datta

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Pregnancy-related anatomic and physiologic changes result in altered pharmacologic and toxicologic responses to local anesthetics. Reductions in serum protein binding have been implicated in enhanced toxic effects. Previous studies have demonstrated these reductions in protein binding only in the term parturient. The present study defines the pattern of protein binding changes of lidocaine throughout gestation. Venous samples were obtained from pregnant patients of varying gestational age, as well as from nonpregnant control patients. The percent free drug at a fixed concentration (2 μg/mL) was determined for each sample using an ultrafiltration technique. The free concentration of lidocaine increased significantly throughout gestation, reflecting a corresponding decrease in protein binding. However, these changes were small compared to those in the nonparturient, which suggests that toxicity to lidocaine should not vary during pregnancy.

Original languageEnglish (US)
Pages (from-to)295-297
Number of pages3
JournalAnesthesia and analgesia
Volume79
Issue number2
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Measurements of protein binding of lidocaine throughout pregnancy'. Together they form a unique fingerprint.

  • Cite this

    Fragneto, R. Y., Bader, A. M., Rosinia, F., Arthur, G. R., & Datta, S. (1994). Measurements of protein binding of lidocaine throughout pregnancy. Anesthesia and analgesia, 79(2), 295-297.