MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS

Daniel P. Nicolella; Eugene Sprague; Lynda Bonewald

doi:10.1115/IMECE1999-0428

MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS

Daniel P. Nicolella, Eugene Sprague, Lynda Bonewald

Division of Cardiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid fluw induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

Original language	English (US)
Title of host publication	Advances in Bioengineering
Publisher	American Society of Mechanical Engineers (ASME)
Pages	163-164
Number of pages	2
ISBN (Electronic)	9780791816400
DOIs	https://doi.org/10.1115/IMECE1999-0428
State	Published - 1999
Event	ASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999 - Nashville, United States Duration: Nov 14 1999 → Nov 19 1999

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume	1999-D

Conference

Conference	ASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999
Country/Territory	United States
City	Nashville
Period	11/14/99 → 11/19/99

ASJC Scopus subject areas

Mechanical Engineering

Access to Document

10.1115/IMECE1999-0428

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Nicolella, D. P., Sprague, E., & Bonewald, L. (1999). MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS. In Advances in Bioengineering (pp. 163-164). (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 1999-D). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE1999-0428

MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS. / Nicolella, Daniel P.; Sprague, Eugene; Bonewald, Lynda.

Advances in Bioengineering. American Society of Mechanical Engineers (ASME), 1999. p. 163-164 (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 1999-D).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Nicolella, DP, Sprague, E & Bonewald, L 1999, MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS. in Advances in Bioengineering. ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), vol. 1999-D, American Society of Mechanical Engineers (ASME), pp. 163-164, ASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999, Nashville, United States, 11/14/99. https://doi.org/10.1115/IMECE1999-0428

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AB - It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid fluw induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

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MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS

Abstract

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