MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS

Daniel P. Nicolella; Eugene Sprague; Lynda Bonewald

doi:10.1115/IMECE1999-0428

MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS

Daniel P. Nicolella, Eugene Sprague, Lynda Bonewald

Division of Cardiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid fluw induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

Original language	English (US)
Title of host publication	Advances in Bioengineering
Publisher	American Society of Mechanical Engineers (ASME)
Pages	163-164
Number of pages	2
ISBN (Electronic)	9780791816400
DOIs	https://doi.org/10.1115/IMECE1999-0428
State	Published - 1999
Event	ASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999 - Nashville, United States Duration: Nov 14 1999 → Nov 19 1999

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume	1999-D

Conference

Conference	ASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999
Country/Territory	United States
City	Nashville
Period	11/14/99 → 11/19/99

ASJC Scopus subject areas

Mechanical Engineering

Access to Document

10.1115/IMECE1999-0428

Cite this

Nicolella, D. P., Sprague, E., & Bonewald, L. (1999). MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS. In Advances in Bioengineering (pp. 163-164). (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 1999-D). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE1999-0428

MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS. / Nicolella, Daniel P.; Sprague, Eugene; Bonewald, Lynda.
Advances in Bioengineering. American Society of Mechanical Engineers (ASME), 1999. p. 163-164 (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 1999-D).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Nicolella, DP, Sprague, E & Bonewald, L 1999, MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS. in Advances in Bioengineering. ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), vol. 1999-D, American Society of Mechanical Engineers (ASME), pp. 163-164, ASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999, Nashville, United States, 11/14/99. https://doi.org/10.1115/IMECE1999-0428

@inproceedings{8072451342574234a4d83a75edd8b16d,

title = "MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS",

abstract = "It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid fluw induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.",

author = "Nicolella, {Daniel P.} and Eugene Sprague and Lynda Bonewald",

note = "Publisher Copyright: {\textcopyright} 1999 American Society of Mechanical Engineers (ASME). All rights reserved.; ASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999 ; Conference date: 14-11-1999 Through 19-11-1999",

year = "1999",

doi = "10.1115/IMECE1999-0428",

language = "English (US)",

series = "ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)",

publisher = "American Society of Mechanical Engineers (ASME)",

pages = "163--164",

booktitle = "Advances in Bioengineering",

}

TY - GEN

T1 - MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS

AU - Nicolella, Daniel P.

AU - Sprague, Eugene

AU - Bonewald, Lynda

PY - 1999

Y1 - 1999

N2 - It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid fluw induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

AB - It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid fluw induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

UR - http://www.scopus.com/inward/record.url?scp=85122708615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85122708615&partnerID=8YFLogxK

U2 - 10.1115/IMECE1999-0428

DO - 10.1115/IMECE1999-0428

M3 - Conference contribution

AN - SCOPUS:85122708615

T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)

SP - 163

EP - 164

BT - Advances in Bioengineering

PB - American Society of Mechanical Engineers (ASME)

T2 - ASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999

Y2 - 14 November 1999 through 19 November 1999

ER -

MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS

Abstract

Publication series

Conference

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this