TY - GEN
T1 - MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS
AU - Nicolella, Daniel P.
AU - Sprague, Eugene
AU - Bonewald, Lynda
N1 - Publisher Copyright:
© 1999 American Society of Mechanical Engineers (ASME). All rights reserved.
PY - 1999
Y1 - 1999
N2 - It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid fluw induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.
AB - It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid fluw induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.
UR - http://www.scopus.com/inward/record.url?scp=85122708615&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85122708615&partnerID=8YFLogxK
U2 - 10.1115/IMECE1999-0428
DO - 10.1115/IMECE1999-0428
M3 - Conference contribution
AN - SCOPUS:85122708615
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
SP - 163
EP - 164
BT - Advances in Bioengineering
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999
Y2 - 14 November 1999 through 19 November 1999
ER -