MEASUREMENT OF OSTEOCYTE DEFORMATION RESULTING FROM FLUID FLOW INDUCED SHEAR STRESS

Daniel P. Nicolella, Eugene Sprague, Lynda Bonewald

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid fluw induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

Original languageEnglish (US)
Title of host publicationAdvances in Bioengineering
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages163-164
Number of pages2
ISBN (Electronic)9780791816400
DOIs
StatePublished - 1999
EventASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999 - Nashville, United States
Duration: Nov 14 1999Nov 19 1999

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume1999-D

Conference

ConferenceASME 1999 International Mechanical Engineering Congress and Exposition, IMECE 1999
Country/TerritoryUnited States
CityNashville
Period11/14/9911/19/99

ASJC Scopus subject areas

  • Mechanical Engineering

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