Measurement of osteocyte deformation resulting from fluid flow induced shear stress

Daniel P. Nicolella; Eugene Sprague; Lynda Bonewald

Measurement of osteocyte deformation resulting from fluid flow induced shear stress

Daniel P. Nicolella, Eugene Sprague, Lynda Bonewald

Department of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm². Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid flow induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publisher	ASME
Pages	163-164
Number of pages	2
Volume	43
ISBN (Print)	0791816400
State	Published - 1999
Event	Advances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition) - Nashville, TN, USA Duration: Nov 14 1999 → Nov 19 1999

Other

Other	Advances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition)
City	Nashville, TN, USA
Period	11/14/99 → 11/19/99

ASJC Scopus subject areas

General Engineering

Cite this

Nicolella, DP, Sprague, E & Bonewald, L 1999, Measurement of osteocyte deformation resulting from fluid flow induced shear stress. in American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 43, ASME, pp. 163-164, Advances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition), Nashville, TN, USA, 11/14/99.

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AU - Sprague, Eugene

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AB - It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid flow induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

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AN - SCOPUS:0033295482

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EP - 164

BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

PB - ASME

T2 - Advances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition)

Y2 - 14 November 1999 through 19 November 1999

ER -

Measurement of osteocyte deformation resulting from fluid flow induced shear stress

Abstract

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ASJC Scopus subject areas

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