Measurement of osteocyte deformation resulting from fluid flow induced shear stress

Daniel P. Nicolella, Eugene Sprague, Lynda Bonewald

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid flow induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages163-164
Number of pages2
Volume43
ISBN (Print)0791816400
StatePublished - Dec 1 1999
EventAdvances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition) - Nashville, TN, USA
Duration: Nov 14 1999Nov 19 1999

Other

OtherAdvances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition)
CityNashville, TN, USA
Period11/14/9911/19/99

ASJC Scopus subject areas

  • Engineering(all)

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