Measurement of mitochondrial respiration in trophoblast culture

A. Maloyan, J. Mele, B. Muralimanohara, L. Myatt

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Pregnancy is a state of oxidative stress, which becomes exaggerated under pathological conditions, such as preeclampsia, IUGR, diabetes and obesity, where placental mitochondrial dysfunction is observed. The majority of investigations utilize isolated mitochondria when measuring mitochondrial activity in placenta. However, this does not provide a complete physiological readout of mitochondrial function. This technical note describes a method to measure respiratory function in intact primary syncytiotrophoblast from human term placenta.

Original languageEnglish (US)
Pages (from-to)456-458
Number of pages3
JournalPlacenta
Volume33
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • Hypoxia
  • Mitochondria
  • Oxygen consumption
  • Placenta
  • Trophoblast

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Measurement of mitochondrial respiration in trophoblast culture'. Together they form a unique fingerprint.

Cite this