Measurement of mitochondrial respiration in trophoblast culture

A. Maloyan, J. Mele, B. Muralimanohara, L. Myatt

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Pregnancy is a state of oxidative stress, which becomes exaggerated under pathological conditions, such as preeclampsia, IUGR, diabetes and obesity, where placental mitochondrial dysfunction is observed. The majority of investigations utilize isolated mitochondria when measuring mitochondrial activity in placenta. However, this does not provide a complete physiological readout of mitochondrial function. This technical note describes a method to measure respiratory function in intact primary syncytiotrophoblast from human term placenta.

Original languageEnglish (US)
Pages (from-to)456-458
Number of pages3
JournalPlacenta
Volume33
Issue number5
DOIs
StatePublished - May 2012
Externally publishedYes

Fingerprint

Trophoblasts
Placenta
Respiration
Fetal Growth Retardation
Pre-Eclampsia
Mitochondria
Oxidative Stress
Obesity
Pregnancy

Keywords

  • Hypoxia
  • Mitochondria
  • Oxygen consumption
  • Placenta
  • Trophoblast

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology

Cite this

Maloyan, A., Mele, J., Muralimanohara, B., & Myatt, L. (2012). Measurement of mitochondrial respiration in trophoblast culture. Placenta, 33(5), 456-458. https://doi.org/10.1016/j.placenta.2012.01.016

Measurement of mitochondrial respiration in trophoblast culture. / Maloyan, A.; Mele, J.; Muralimanohara, B.; Myatt, L.

In: Placenta, Vol. 33, No. 5, 05.2012, p. 456-458.

Research output: Contribution to journalArticle

Maloyan, A, Mele, J, Muralimanohara, B & Myatt, L 2012, 'Measurement of mitochondrial respiration in trophoblast culture', Placenta, vol. 33, no. 5, pp. 456-458. https://doi.org/10.1016/j.placenta.2012.01.016
Maloyan, A. ; Mele, J. ; Muralimanohara, B. ; Myatt, L. / Measurement of mitochondrial respiration in trophoblast culture. In: Placenta. 2012 ; Vol. 33, No. 5. pp. 456-458.
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