McArdle disease presenting as acute renal failure

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5 Scopus citations


In 1951, McArdle described a glycogen storage disorder which presents primarily as a myopathy. It is characterized by muscle pain, weakness and exercise intolerance with elevated creatine kinase from rhabdomyolysis. The pathophysiology involves a deficiency of myophosphorylase enzyme resulting in an inability to degrade glycogen stores. We present a novel case of McArdle disease (glycogen storage disease V [GSDV]) in a patient who had sickle cell trait and bulimia. The disease went unrecognized despite several admissions to the hospital with increased creatine kinase and muscle myopathy until the patient's initial presentation with acute renal failure.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalSouthern medical journal
Issue number3
StatePublished - Mar 1 2007
Externally publishedYes


  • Bulimia
  • Glycogen storage disease V
  • GSDV
  • McArdle disease
  • Sickle cell trait

ASJC Scopus subject areas

  • Medicine(all)


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